Ikaria Inc.

Other

Fred Hutchinson Cancer Center

Edward A Wintner

Thomas L Deckwerth

Kevin J Tomaselli

Fuqiang Ruan

Csaba Szabo

Paul A Hill

Julius M Rebek, Jr

Thomas Carell

Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.

Compounds, compositions and methods for treating or preventing hypoxic or ischemic injury

The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.

Liquid chalcogenide compositions and methods of manufacturing and using the same

A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I):R&#x2014;(S)&#x2014;R&#x2003;&#x2003;(I)or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R, R, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compositions and methods for treating or preventing hypoxic or ischemic injury

Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.

Growing community of inventors

Belmont, MA, United States of America

Edward A Wintner