Lacer, S.a.

Lacer

Eduardo Salas Perez-Rasilla

Francisco Pubill Coy

Jose Repolles Moliner

Lydia Cabeza Llorente

Marcelli Carbo Banus

Cristina Negrie Rofes

Alicia Ferrer Siso

Marek W Radomski

Juan Martinez Bonnin

Jos&eacute; Repolles Moliner

Juan-Antonio Cerda Riudavets

Jes&uacute;s Murat Moreno

Juan Antonio Cerda Riudavets

Nuria Trias Adroher

Pedro Michelena Llagundo

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: as well as pharmaceutical compositions comprising these compounds and uses thereof.

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof as well as pharmaceutical compositions comprising these compounds and uses thereof. 

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups&#x2014;ONOand &#x2014;Z&#x2014;CO&#x2014;R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, or the groupin which Ris hydrogen, or an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always &#x2014;ONO, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance

S-nitrosothiols as agents for the treatment of circulatory dysfunctions

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Barcelona, Spain

Eduardo Salas Perez-Rasilla