The University of North Carolina at Chapel Hill

Other

Eduardo R Lazarowski

Richard C Boucher

Monroe Jackson Stutts

Cara A Geary

Janet L Rideout

Benjamin R Yerxa

William Pendergast

Karla M Jacobus

David J Drutz

Michael K James

Cara Geary

The present invention is directed to a method of stimulating ciliary beat frequency to promote mucociliary or cough clearance of retained mucus secretions from the lungs, sinuses, upper airways, ears, eyes, genito-urinary tract, spermatozoa, ovaries, fallopian tubes, neutrophils, and macrophages of a patient. The method comprises administering uridine triphosphates, adenosine triphosphates, cytidine triphosphates, or dinucleoside tetraphosphates and the derivatives thereof to an affected body of a patient, to treat dysfunction of the mucociliary clearance system as a result of impaired ciliary movement in the patient.

Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues

A pharmaceutical formulation comprises, in an amount effective to hydrate lung mucous secretions, a compound of Formula (I):

Dinucleotides useful for the treatment of lung disease

A pharmaceutical formulation comprises, in an amount effective to hydrate lung mucous secretions, a compound of Formula (I): ##STR1## wherein n is from 1 to 6;

Dinucleotides useful for hydrating lung mucous secretions

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed: ##STR1## wherein: n is from 1 to 6;

Dinucleotides useful for the treatment of cystic fibrosis and for

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Durham, NC, United States of America

Eduardo R Lazarowski