Indena S.p.a.

Vivacell Biotechnology Espana, S.l.

Eduardo Munoz Blanco

Giovanni Appendino

Maria Luz Bellido Cabello De Alba

Alberto Minassi

Alberto Pagani

Cristina Cruz Teno

Carmen Maria Navarrete Rueda

Triterpenoid derivatives and compositions comprising said triterpenoids derivatives of Formula (I) are described, wherein R&#x2550;&#x2014;C(O)NHOH. Said triterpenoids and compositions show capacity to bind PHD2, stabilize HIF-1&#x3b1; and HIF-2&#x3b1; proteins, activate the HIF pathway in different cell types, induce angiogenesis in human endothelial vascular cell, show neuroprotective activity in vitro and in vivo, antidiabetic activity and reduce the levels of lipids in vivo, and increase the plasma levels of Erythropoietin in vivo. The triterpenoid derivatives described act also in a selective manner and do not induce Nrf2 activation, NF-&#x3ba;B inhibition, STAT3 inhibition, and TGR5 activation, which are known activities of the natural triterpenoid precursors. Said triterpenoid derivatives are useful in the treatment of conditions and diseases which are responsive to HIF activation such as stroke, cerebral palsy, traumatic injuries and neurodegenerative diseases; and also IBD, myocardial ischaemia-reperfusion injury, acute lung injury, diabetic and chronic wounds, organ transplantation, acute kidney injury or arterial diseases. 

Hydroxamate triterpenoid derivatives

The present invention relates to a new method for isolating ingenol (CHO) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate.

Method of isolating ingenol

Growing community of inventors

Cordova, Spain

Eduardo Munoz Blanco