Centro De Ingenieria Genetica Y Biotecnologia

Centro De Ingenieria Genetica Y Biotechnologia

Eduardo Martinez Diaz

Luis Javier González López

Lila Rosa Castellanos Serra

Jorge Victor Gavilondo Cowley

Ana Aguilera Barreto

Manuel Selman-Housein Sosa

Mónica Bequet Romero

José Garcia Suárez

Beatriz Torrez Cabrera

Raúl Gómez Riera

Karelia Cosme Diaz

Milesa Yeni Sarmiento Mayea

Maria Del Carmen Abrahantes Pérez

Caridad Anais Gasmuri González

Beatriz Tamargo Santos

Jesús Reyes González

Maria Acelia Marrero Miragaya

Lisette Gonzalez Chavez

Luciano Francisco Hernandez Marrero

Gloria Véliz Rios

Pharmaceutical formulations in suppository form, containing thrombolytic agents, which are able to penetrate rectal mucous, for the treatment of acute hemorrhoid diseases and/or diseases of thrombotic origin.

Formulations for the rectal administration of thrombolytically-active agents

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's 'in vivo' administration has antitumoral, antiangiogenic and protective effect against malignant tumors.

Pharmaceutical composition containing polypeptide fragments of serralysins

Growing community of inventors

Ciudad Habana, Cuba

Eduardo Martinez Diaz