The Scripps Research Institute

Eduardo Laborda

Leonard G Presta

Peter G Schultz

Travis Young

Chanhyuk Kim

Ian Hardy

Leonard Presta

Eric Hampton

David T Rodgers

Timothy Wright

Elvira Khialeeva

Sophie Viaud

Travis S Young

David Rodgers

The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof

Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

Optimized PNE-based chimeric receptor T cell switches and uses thereof

Growing community of inventors

La Jolla, CA, United States of America

Eduardo Laborda