The Brigham and Women's Hospital, Inc.

Eduard Y Chekmenev

Samuel Patz

Natalia V Lisitza

A method of preparing a hydrogen-containingC compound test sample exhibiting an enhancedC nuclear magnetic resonance (NMR) signal when exposed to aC NMR pulse sequence is disclosed. In the disclosed method, the hydrogen-containingC compound is mixed with hyperpolarizedXe in the gaseous state, and the mixture is subsequently frozen within a magnetic field. The magnetic field strength is then reduced sufficiently so that spin polarization is transferred from the hyperpolarizedXe to the compound. The magnetic field strength is then increased, and the mixture is thawed to obtain the test sample.

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Nashville, TN, United States of America

Eduard Y Chekmenev