Vanderbilt University

Southern Illinois University

Duke University

University of California

Eduard Y Chekmenev

Boyd M Goodson

Roman V Shchepin

Fan Shi

Aaron M Coffey

Warren S Warren

Thomas Theis

Bryce E Kidd

Milton L Truong

Danila A Barskiy

Quinn A Best

Yuqing Hou

Miranda Limbach

Jamil A Mashni

Ping He

Kirsten A Groome

Igor V Koptyug

Kirill V Kovtunov

Jonathan Gesiorski

Max E Gemeinhardt

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

Cleavable agents

The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.

Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP

Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.

Method for creating hyperpolarization at microTesla magnetic fields

Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.

Method for creating hyperpolarization at microtesla magnetic fields

Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.

Methods of detecting sulfur-containing compounds

Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Water soluble catalysts for NMR/MRI enhancement

Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Heterogeneous catalysts for NMR/MRI enhancement via signal amplification by reversible exchange (SABRE)

Growing community of inventors

Brentwood, TN, United States of America

Eduard Y Chekmenev