Thermo Fisher Scientific (bremen) Gmbh

Thermo Finnigan LLC

Thermo Fisher Scientific Gmbh

Eduard V Denisov

Alexander Alekseevich Makarov

Wilko Balschun

Gerhard Jung

Alexander Kholomeev

Jens Griep-Raming

Dirk Nolting

Stevan Roy Horning

Jan-Peter Hauschild

Oliver Lange

Dmitry E Grinfeld

Denis Chernyshev

Robert Malek

Alexander A Makarov

Nicolaie Eugen Damoc

Gregor Quiring

Mikhail Belov

Aivaras Venckus

Martin Zeller

Joachim Müller

Oliver C/O Thermo Fischer Scientific Gmbh Lange

Alexander Alekseevich C/O Thermo Fischer Scientific Gmbh Makarov

Alexander Makarov

Wilko c/o Thermo Electron Gmbh Balschun

The present invention provides a mass spectrometer comprising a first ion trap, a second ion trap, a lens stack for directing ions from the first ion trap to the second ion trap and a housing. The first ion trap is arranged to form a linear or curved potential well and the second ion trap is an electrostatic ion trap, for example, an orbital ion trap, arranged to form an annular potential well. The mass spectrometer further comprises a unitary insert comprising a first cavity which holds the lens stack and a second cavity which holds the second ion trap, wherein the insert is inserted within the housing.

Mass spectrometer using unitary insert between first and second ion traps

The present invention provides an electrode arrangementfor an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangementcomprises an RF electrode' mechanically coupled to a dielectric material. The RF electrode′ is mechanically coupled to the dielectric materialby a plurality of separatorsthat are spaced apart and configured to define a gap between the RF electrode′ and the dielectric material. Each of the plurality of separatorscomprises a projecting portionand the dielectric materialcomprises corresponding receiving portionssuch that on coupling of the RF electrode′ to the dielectric material, the projecting portionof each separatoris received within the corresponding receiving portiona of the dielectric material. The present invention also relates to an ion trap comprises the electrode arrangementand a method of manufacturing the electrode arrangement

Electrode arrangement

Ions are injected into an orbital electrostatic trap. An ejection potential is applied to an ion storage device, to cause ions stored in the ion storage device to be ejected towards the orbital electrostatic trap. Synchronous injection potentials are applied to a central electrode of the orbital electrostatic trap and a deflector electrode associated with the orbital electrostatic trap, to cause the ions ejected from the ion storage device to be captured by the electrostatic trap such that they orbit the central electrode. Application of the ejection potential and application of the synchronous injection potentials are each started at respective different times, the difference in times being selected based on desired values of mass-to-charge ratios of ions to be captured by the orbital electrostatic trap.

Ion injection to an electrostatic trap

The present invention provides an electrode arrangement' for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement&#x2032; comprises an RF electrode&#x2032; mechanically coupled to a dielectric material. The RF electrode&#x2032; is mechanically coupled to the dielectric materialby a plurality of separatorsthat are spaced apart and configured to define a gap between the RF electrode&#x2032; and the dielectric material. Each of the plurality of separatorscomprises a projecting portionand the dielectric materialcomprises corresponding receiving portionssuch that on coupling of the RF electrode&#x2032; to the dielectric material, the projecting portionof each separatoris received within the corresponding receiving portionof the dielectric material. The present invention also relates to an ion trap comprises the electrode arrangement&#x2032; and a method of manufacturing the electrode arrangement

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3d5;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3d5;, z) is the result of a perturbation W to an ideal field U(r, &#x3d5;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3d5;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2&#x3c0; radians over an ion detection period T.

Electrostatic trap

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3d5;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3d5;, z) is the result of a perturbation W to an ideal field U(r, &#x3d5;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3d5;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

The present disclosure provides a mass spectrometer for performing an analysis of sample ions, and a method for operating a mass spectrometer. The mass spectrometer comprises a first ion optical element that is supplied with a first gas; a mass analyzer, wherein the performance of the mass analyzer is dependent on the pressure of the first gas in the first ion optical element; and a controller for setting a property of the first gas, which comprises at least the pressure of the first gas, on the basis of a characteristic of the analysis to be performed by the mass spectrometer.

Mass spectrometer

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3c6;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3c6;, z) is the result of a perturbation W to an ideal field U(r, &#x3c6;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3c6;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

An ion guide for mass spectrometry comprising an electrode arrangement of at least two electrodes, at least one of which is an RF electrode, arranged adjacent to each other but spaced apart on a planar surface of a dielectric material and arranged at a distance from an ion flow path, wherein a portion of the dielectric surface is exposed between an adjacent pair of the spaced apart electrodes and wherein at least one electrode of said adjacent pair of electrodes is arranged to overhang the exposed portion of surface between them such that there is no direct line of sight from the ion flow path to the exposed portion of dielectric surface. The device enables RF guiding of ions accompanied by much reduced charging-up of dielectric surfaces and reduced amount of collisions of neutral species with electrodes.

Ion guide

The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.

RF power supply for a mass spectrometer

A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

Collision cell

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r, &#x3a6;, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U&#x2032;(r, &#x3a6;, z) is the result of a perturbation W to an ideal field U(r, &#x3a6;, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, &#x3a6;, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 &#x3c0; radians over an ion detection period T.

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Bremen, Germany

Eduard V Denisov