Teva Pharmaceutical Industries Limited

Eduard Gurevich

Anton Frenkel

Avital Laxer

Ramy Lidor-Hadas

Gsan Attili

Disclosed is a process for the preparation of laquinimod sodium which removes the impurities after the salt formation step, thus resulting in crystals of higher purity as well as crystals having improved crystalline characteristics.

Crystals of laquinimod sodium, and process for the manufacture thereof

Disclosed is a process for the preparation of laguinimod sodium which removes the impurities after the salt formation step, thus resulting in crystals of higher purity as well as crystals having improved crystalline characteristics.

A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan, a process for isolating from a reaction mixture a crystalline diastereomeric salt of a mono-propargylated aminoindan, and a process for isolating from a reaction mixture a salt of enantiomerically pure N-propargyl-1-aminoindan or a salt of enantiomerically pure 6-(N-methyl, N-ethyl-carbamoyloxy)-N'-propargyl-1-aminoindan. The corresponding products are also disclosed.

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Petach Tikva, Israel

Eduard Gurevich