Sanford-Burnham Medical Research Institute

Sanford Burnham Prebys Medical Discovery Institute

Eduard A Sergienko

Anthony B Pinkerton

Robert J Ardecky

Jiwen Zou

Jose Luis Millan

Hampton Sessions

Santhi Reddy Ganji

Marcos Gonzalez-Lopez

Stephen Gardell

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof

Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. In some embodiments, EBI2 is a therapeutic target for the treatment of diseases or conditions such as, but not limited to, autoimmune diseases or conditions, cancer, and cardiovascular disease.

Spirocyclic EBI2 modulators

Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. EBI2 is a therapeutic target for the treatment of a variety of diseases or conditions. In some embodiments, EBI2 is a therapeutic target for the treatment of diseases or conditions such as, but not limited to, autoimmune diseases or conditions, cancer, and cardiovascular disease.

EBI2 modulators

Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.

Growing community of inventors

San Diego, CA, United States of America

Eduard A Sergienko