University System of Maryland

US Government as Represented by the Secretary of the Army

Edson X Albuquerque

Michael S Adler

Edna F R Pereira

Roberto Takashi Sudo

Claudia Lucia Martins Da Silva

Gisele Zapata Sudo

Edna Fr Pereira

Newton Goncalves De Castro

Wagner Monteiro Cintra

Patricia Dias Fernandes

Carlos Alberto Manssour Fraga

Paulo De Assis Melo

Ana Luisa Palhares De Miranda

Yasco Aracava

Eliezer J De Barreiro

Francois Germain Noel

Edna F Pereira

The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therapeutically effective amount of galantamine or a salt thereof, or a biologically active analog, derivative, fragment or variant thereof.

Method of treating organophosphorous poisoning

A method for treating organophosphorous poisoning (OP) comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine.

A method of treating organophosphorous (OP) poisoning comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine.

The invention discloses a compound having the formula (I) wherein Ris selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; Ris selected from the group consisting of H, alkene, un-substituted phenol, and substituted phenyl; and pharmaceutically acceptable salts thereof, having digitalis-like properties. The invention further discloses a novel method to synthesize 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294). LASSBio-294 produces positive inotropic effect on cardiac and skeletal muscle. The invention is useful for the treatment of congestive heart failure and muscle fatigue. It lacks toxic effects seen in digitalis glycosides.

Thienylhydrazon with digitalis-like properties (positive inotropic effects)

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Baltimore, MD, United States of America

Edson X Albuquerque