City of Hope

California Institute of Technology

Edouard M Cantin

John J Rossi

Dongho Kim

John A Zaia

Patric Lundberg

Pairoj Chang

Sarkis K Mazmanian

R Bruce Wallace

Chandran Ramakrishna

The present disclosure includes compositions of a zwitterionic polysaccharide (e.g.,capsular polysaccharide A (PSA)) (including active fragments thereof) and methods of treating viral infection and viral infection associated inflammation with compositions of a zwitterionic polysaccharide (e.g.,capsular polysaccharide A (PSA)) (including active fragments thereof).

Compositions of and methods of treatment with zwitterionic polysaccharide

Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in vitro.

Double-stranded and single-stranded RNA molecules with 5' triphosphates and their use for inducing interferon

Double-stranded and single-stranded RNA molecules with 5' Triphosphates and their use for inducing interferon

Ribozymes useful to cleave HIV-1 and other viral or endogenous cellular RNAs are disclosed. Also disclosed are transformed cells which express such ribozymes and human AIDS therapy involving the administration of such ribozymes.

Ribozyme cleavage of HIV RNA

Stable, catalytic efficient ribozymes useful, inter alia, to cleave HIV-I RNA or any other viral or endogenous cellular RNA, in vitro and in vivo, cells transformed with such ribozymes and the use of such ribozymes and cells for anti-AIDs therapy are disclosed.

Ribozyme cleavage of HIV-I RNA

A method of inhibiting human immunodeficiency virus (HIV) comprising administering a therapeutically effective amount of an antiviral agent to attack the first splice acceptor site of the tat III gene of HIV.

Growing community of inventors

Los Angeles, CA, United States of America

Edouard M Cantin