Sooft Italia Spa

Fidia Farmaceutici S.p.a.

Edoardo Stagni

Giovanni Cavallo

Pierre Roy

Fulvio Foschini

Giulio Luciani

Massimo Filippello

Piero Biondi

Marco Biondi

Marcello Stagni

Eugenio Sodo

It is described a complex of riboflavin into hydroxypropylated &#x3b2;-cyclodextrins as photosensitizer in the riboflavin-UV mediated cross-linking of corneal collage fibers and the relative ophthalmic compositions comprising it.

Cross-linking agents of collagen fibers for the use in the treatment of corneal ectasia

Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm; thereby obtaining the corneal cross-linking of the solution.

Device and method for corneal delivery of riboflavin by iontophoresis for the treatment of keratoconus

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Catania, Italy

Edoardo Stagni