Genentech, Inc.

Aragon Pharmaceuticals, Inc.

Seragon Pharmaceuticals, Inc.

Edna Chow Maneval

Jeffrey H Hager

Nicholas D Smith

Steven P Govek

Mehmet Kahraman

Isan Chen

Debasish F Roychowdhury

Lori Friedman

Deepak Sampath

Mark R Herbert

Jing Qian

James David Joseph

Boa Tran H Troung

Boa Tran H Truong

Jeffrey J Hager

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Estrogen receptor modulators and uses thereof

Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.

Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer

Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.

Methods and compositions for modulating estrogen receptor mutants

Azetidine estrogen receptor modulators and uses thereof

Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.

Androgen receptor modulator and uses thereof

Growing community of inventors

Del Mar, CA, United States of America

Edna Chow Maneval