Braintree Laboratories, Inc.

Other

Nabi Biopharmaceuticals, Inc.

Edmund V Dennett, Jr

Russell W Pelham

Mark vB Cleveland

Mark Cleveland

Robert M Raleigh

Matthew Walker

Bruce H Aronson

David S Wells

Matthew Dean Walker

Robert M Raleigh, Jr

Mark V B Cleveland

Mark Vb Cleveland

Vivian Caballero

Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Methods of administering safe colon cleansing compositions

Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.

Solid oral sulfate salt formulations for cleaning a colon and methods of using same

Solid oral sulfate salt formulations for cleansing a colon and methods of using same

The present invention is generally directed to an oral pharmaceutical tablet composition comprising a sulfate salt, for example, sodium sulfate, wherein the composition is capable of administration by direct oral ingestion and by disintegration in water prior to oral ingestion. The present invention is further directed to use of such oral pharmaceutical tablet formulations to induce laxation or to treat or prevent constipation.

Dual use oral pharmaceutical composition tablets of sulfate salts and methods of use thereof

Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic ravages, or smaller volume hypertonic lavages.

Method of bowel cleansing

A composition for inhibiting gastrointestinal absorption of phosphorous in an individual. The composition includes a quantity of calcium acetate sufficient to bind the phosphorous in the gastrointestinal tract of the individual. The calcium acetate has a bulk density of between 0.50 kg/L and 0.80 kg/L and is dimensioned to form a caplet for fitting within a capsule in a manner that optimizes the volume of the capsule. Also provided is a method for administering the calcium acetate composition of the present invention to an individual to reduce phosphorous absorption by binding with the phosphorous in their gastrointestinal tract.

Encapsulated calcium acetate caplet and a method for inhibiting gastrointestinal phosphorous absorption

Growing community of inventors

Walpole, MA, United States of America

Edmund V Dennett, Jr