Scios Inc.

Scios Nova, Inc.

California Biotechnology Inc.

Edmund G Tischer

Judith A Abraham

John C Fiddes

Richard L Mitchell

Barbara Cordell

Stewart A Thompson

Jeffrey N Higaki

There are disclosed neurotrophic factors which are capable of being expressed as polypeptides lacking the microheterogeneity associated with a related native-sequence factor, CNTF. Also disclosed are DNA sequences encoding the neurotrophic factors and methods for expressing and recovering the factors as homogeneous polypeptides.

Production of homogeneous truncated CNTF

Isolated DNA sequences, expression vectors and transformant cells are provided which allow for the large scale production of vascular endothelial cell growth factor. The vascular endothelial cell growth factor is useful in the treatment of wounds in which neovascularization or reendothelialization is required for healing.

DNA sequences encoding bVEGF120 and hVEGF121 and methods for the

There is described an isolated vascular endothelial cell growth factor selected from the group consisting of bovine vascular endothelial cell growth factor of 120 amino acids and human vascular endothelial cell growth factor of 121 amino acids. The vascular endothelial cell growth factor is useful in the treatment of wounds in which neovascularization or reendothelialization is required for healing.

Production of vascular endothelial cell growth factor

Growing community of inventors

Palo Alto, CA, United States of America

Edmund G Tischer