Rutgers, the State University of New Jersey

University of Medicine and Dentistry of New Jersey

Alteon Incorporated

Taxis Pharmaceuticals, Inc.

Synvista Therapeutics, Inc.

Edmond Joseph LaVoie

Leroy Fong Liu

Ajit S Parhi

Daniel S Pilch

Alexander L Ruchelman

Malvika Kaul

Yongzheng Zhang

Stanley Charles Bell

Dilip R Wagle

Martin Gall

Joseph E Rice

Hye Yeon Sagong

Kalyan Das

Jung Sun Kim

Joseph David Bauman

Eddy Arnold

Qun Sun

Sudhir K Singh

Gifty A Blankson

Disha Patel

Suyambu Kesava Vijayan

Meera Rangarajan

Yangsheng Sun

Yi Yuan

John J Egan

Sara Vasan

Ajit K Parhi

Darshan B Makhey

Wei Feng

Abhijit Ray

John E Kerrigan

Baoping Zhao

Liping Wang

Cody Kelley

Dishaben V Patel

Xiao Chen

Edgar Ferrer-González

Suzanne G Rzuczek

Satyanarayana Mavurapu

Younong Yu

The invention provides a compound of formula I: or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.

Fluorescent probes for the visualization of FtsZ in gram-positive and gram-negative bacterial pathogens

Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.

Indole derivatives as efflux pump inhibitors

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Bacterial efflux pump inhibitors

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

Therapeutic compounds and methods to treat infection

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor. 

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound: 

Antimicrobial agents

Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I). 

Topoisomerase poisons

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.

Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer

The invention provides compounds of formula (I): wherein R-R, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

The invention provides compounds of formula I: and salts and prodrugs thereof wherein R, Xand Xhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

Growing community of inventors

Princeton Junction, NJ, United States of America

Edmond Joseph LaVoie