Ucb S.a.

Ciba-geigy Corporation

Alliedsignal Inc.

Ucb Pharma, S.a.

Uob Pharma, S.a.

Edmond Differding

Philippe Michel

Patrice Talaga

Patrick Pasau

Alain Matagne

Jaroslav Stanek

Marc Lang

Benoît Kenda

Bénédicte Lallemand

Xiong Cai

Timothy A Lewis

Pierre P Chatelain

Sajjat Hussoin

Gurmit Grewal

Anna Toy-Palmer

Ralph Scannell

James Ellis

Marie-Agnes Lassoie

B&eacute;n&eacute;dicte Lallemand

Beno&icirc;t Kenda

Jean-Pierre Jules Geerts

Genevieve Motte

Jean-Pierre Henichart

Michelle Young

The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.

2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses

2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses

The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I,wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.

2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Compounds and methods for treatment of asthma, allergy and inflammatory disorders

The invention concerns 2-oxo-1-pyrrolidine derivatives of formula (I) wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These compounds have the general formula ##STR1## wherein n=1 or 2,

Substituted 1H-imidazoles

Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

.alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivatives

The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.

N-fluorosulfonimides and their application as fluorinating agents

4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile

Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

.alpha.-fluoro-.alpha.-(1,2,3-triazolyl)-phenylmethyl derivatives useful

.alpha.-fluoro-.alpha.-tetrazolyl-phenylmethyl derivatives useful as

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Louvain-la-Neuve, Belgium

Edmond Differding