Acelrx Pharmaceuticals, Inc.

Vertical Pharmaceuticals, Inc.

Aceirx Pharmaceuticals, Inc.

Edmond Chiu

Andrew I Poutiatine

Bruce P Edwards

Pamela Palmer

Stelios Tzannis

Charles Rampersaud

Thomas A Schreck

William Kolosi

Sascha Retailleau

Lawrence Hamel

Larry Hamel

Bruce Edwards

Casidy Domingo

Bradley Blackwood

Thomas Schreck

Single dose drug dosage form dispensing devices, and methods for operating such devices are disclosed herein. In one embodiment, an apparatus includes a housing defining an actuation pathway and a pusher. At least a portion of the pusher is disposed within the actuation pathway such that distal end portions of the pusher and the housing define a volume configured to contain a drug-containing tablet. The pusher is configured to move relative to the housing in a distal direction from a first position to a second position to expel the tablet from the volume. The distal end portion of the pusher is extended from an opening in the housing when the pusher is in its second position. The housing is configured to limit movement of the pusher relative to the housing in a proximal direction towards the first position of the pusher after the tablet is expelled.

Apparatus and methods for dispensing oral transmucosal dosage forms

An apparatus includes a housing and a pushrod. The housing defines a delivery passage and an exit port in fluid communication with the delivery passage. At least a portion of the pushrod is movably disposed in the delivery passage. A distal end portion of the pushrod is configured to move a drug dosage form through at least a portion of the delivery passage to convey the drug dosage form through the exit port when the distal end portion of the pushrod is moved from a first position to a second position. A surface of at least one of the pushrod or the housing defining the delivery passage is nonplanar, curved and/or contoured.

Systems, devices and methods for dispensing oral transmucosal dosage forms

Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Apparatus for administering small volume oral transmucosal dosage forms

Methods and apparatus for administering small volume oral transmucosal dosage forms

Methods for administering small volume oral transmucosal dosage forms using a dispensing device

Drug storage and dispensing devices for dispensing dosage forms to the oral mucosa of a patient are disclosed. The drug storage and dispensing device is a single dose applicator or a device which includes a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Storage and dispensing devices for administration of oral transmucosal dosage forms

A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.

Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms

Growing community of inventors

San Francisco, CA, United States of America

Edmond Chiu