University of Southern California

Biomedical Systems Corporation

Edmond A Jonckheere

William Stuppy

Roberto Martin Del Campo Vera

Fariba Ariaei

Mingji Lou

Timothy Callahan

Methods, systems, and apparatus for detecting rhythmic synchronization of motor neurons. The system includes one or more sensors for receiving a first signal that measures an electrical signal of one or more neurons, the first signal having a first plurality of specific bursts. The system includes a processor connected to the one or more sensors. The processor is configured to receive the first signal. The processor is configured to generate a second signal based on the first signal using a discrete wavelet transform, the second signal having a second plurality of specific bursts. The processor is configured to determine a time delay between a specific burst within the first plurality of specific bursts and a specific burst within the second plurality of specific bursts using one or more expert rules. The processor is configured to apply the time delay to the first signal.

Rhythmic synchronization of motor neuron discharges and their burst rate variability

A system for detecting a spinal injury region containing injured spinal nerve cells may include a swarm of nanosensors that are configured to detect chemical signals released by the injured spinal nerve cells, and are coated with a magnetic material. A magnetic field generator may controllably generate a magnetic field so as to magnetically levitate the magnetically coated nanosensors. An imaging subsystem may detect the positions of the nanosensors. A controller may control the intensity and direction of the magnetic field in a feedback loop, in response to the detected positions of the nanosensors, so that the attractive force that attracts each nanosensor toward the injured spinal cell as a result of the chemical affinity of the nanosensor is iteratively supplemented by the magnetic levitation force applied to that nanosensor, until substantially all of the nanosensors are agglutinated around the spinal injury region.

Spinal injury imaging by magnetically levitated sensors

Electrocardiogram data is received in association with a subject, the electrocardiogram data comprising a series of RR intervals and a series of QT intervals. A first value which indicates an amount by which uncertainty associated with the QT intervals is reduced given the RR intervals is generated. A second value which indicates an amount by which uncertainty associated with the RR intervals is reduced given the QT intervals is generated. The subject is determined to be associated with a low risk of cardiac dysfunction responsive to the first value exceeding the second value and a result of the determination is provided.

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Edmond A Jonckheere