Brown University

Massachusetts Institute of Technology

Chamber Works, LLC

Alkermes Controlled Therapeutics, Inc.

Neurotech S.a.

Perosphere Inc.

Cytec Technology Corporation

Acusphere, Inc.

Capitol Specialty Plastics, Inc.

Perosphere Technologies Inc.

Therapyx, Inc.

Thebapyx, Inc.

Edith Mathiowitz

Jules S Jacob

Robert Samuel Langer

Donald E Chickering, Iii

Yong S Jong

Bryan Laulicht

Abraham J Domb

Christopher D Thanos

Ellen Jorgensen

Patrick Duffy

Erich Boger

Gerardo P Carino

Howard Bernstein

Solomon S Steiner

Zhi Liu

Sasha Bakhru

Kim Boekelheide

Yong Shik Jong

Eyal S Ron

Cato T Laurencin

Gershon Golomb

Ernest G Cravalho

Nejat Egilmez

Steven Giannos

Kathleen Jo Pekarek

Stacia Furtado

Donald Chickering

Camila A Santos

Benjamin A Hertzog

Rohit Kothari

Thomas Conway

Kirsten Schwaller

Eric Morrel

Edwin E Edwards

Bryan E Laulicht

Elazer Reuven Edelman

Alexander M Klibanov

Ihab M Hekal

Julie A Straub

Jeffrey R Morgan

Abraham Warshawsky

Henry T Brush

Richard Hopkins

Richard E Wing

Robert S Langer

Anthony Napolitano

Dylan Dean

Wendy L Webber

Kathleen Jo Leach

Peter Chai

Danya Lavin

Elazar Edelman

Daniel Cho

Michael Klagsburn

Joshua Reineke

Thomas R Beck

Diana M James

Claudy Jp Mullon

Sasha H Bakhru

Nicholas R Labriola

Eric M Darling

Patrick Joseph Duffy

Erich Theodore August Boger

Ellen Dias Jorgensen

Compositions and methods are provided for making hyper compliant polymer particles by inverse emulsification and having a predetermined mechanical compliance and a predetermined size with a monodisperse diameter. Compositions and methods are provided for use of hyper compliant polymer particles in drug delivery, assay, particle image velocimetry, ceramics, cosmetics, deconvolution, electronic paper, insulation, personal care, standards, retroreflective paint and paint applications, thickening agents, regenerative medicine, device calibration, micro-carriers and force indicators.

Methods of fabricating hyper compliant polymer particles and methods of use and compositions

Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive agents are in the form of micro- or nanoparticles. The crystalline matrix confers enhanced stability to the agents embedded therein relative to other microparticulate or nanoparticulate bioactive agents. The carriers are especially useful for stabilizing bioactive macromolecules, such as proteins.

Compositions for stabilizing and delivering proteins

Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or micro articles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines.

Methods for effectively and rapidly desensitizing allergic patients

Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.

Anticoagulant reversal agents

Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.

Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof

Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments.

Methods and devices for encapsulating cells

Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold.

Compositions, methods and kits for therapeutic treatment with wet spun microstructures

An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents that are nanoparticulated or nanoencapsulated. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.

Methods and systems for prolonged localization of drug delivery

An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.

Diuretic bioactivity profiles of phase inversion micronized furosemide and furosemide co-precipitated with Eudragit L100, and mixtures of those formulations with stock furosemide, reduced or eliminated the rapid spike in diuresis associated with immediate release formulations and maintained cumulative urine output. Of the formulations tested, each of a mixture of micronized furosemide with stock furosemide, and Eudragit L100 polymer with stock furosemide demonstrated optimal diuretic bioactivity profiles in subjects.

Compositions and methods for loop diuretics with consistent bioavailability

Growing community of inventors

Brookline, MA, United States of America

Edith Mathiowitz