The United States of America, as Represented by the Secretary, Department of Health and Human Services

The United States of America as Represented by the Department of Health

University of Medicine and Dentistry of New Jersey

Edith C Wolff

Myung Hee Park

Hartmut M Hanauske-Abel

Hynda K Kleinman

Paul M Clement

Bernadette M Cracchiolo

Judit Jakus

John E Folk

A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound. 

Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation

Compositions and methods for the treatment of mammalian cells to inhibit cell growth, especially for inhibiting the proliferative cell growth associated with malignant and non-malignant disease, are provided. More particularly, a deoxyhypusine synthase inhibitor, typically, a mono- or bisguanyl diamine or polyamine, is administered to the cells. Also provided by this invention are diagnostic methods and kits for screening the cells of a patient to determine the effect of the deoxyhypusine synthase inhibitor on proliferation of the cells.

Compositions and methods for inhibiting deoxyhypusine synthase and the

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Bethesda, MD, United States of America

Edith C Wolff