Richter Gedeon Vegyeszeti Gyar Rt

Richter Gedeon Vlcyeszeti Gyar Rt.

Edit Toth

Laszlo Szporny

Eva Palosi

Jozsef Torley

Sandor Gorog

Istvan Hajdu

Csilla Meszaros

Bela Kiss

Istvan Laszlovszky

Szabolcs Szeberenyi

Imre Klebovich

Laszlo Vereczkey

Gyorgy Fekete

Erzsebet Lapis

Dora Groo

Pal Vittay

Szaboles Szeberenyi

Ferenc Auth

Laszlo Gaal

Szabolcz Szeberenyi

Gyorgy Hajos

Egon Karpati

Bela Hegedus

Zsolt Szombathelyi

Katalin Csomor

Aniko Gere

Judit Laszy

Adam Sarkadi

Ferenc Simon

Andrea Maderspach

Mihaly Bodo

Andras Javor

Zsolt Szentirmay

Peter Sarkozy

Andras Selmeczi

Szaholes Szeberenyi

Szabolos Szeberenyi

Szabolcs Szebereneyi

Sander Gorog

PerjeIstvan

Lao Szporny

Attila Misley

Jozsef Turley

Laszlo Haal

Jozef Torley

Groo

The invention relates to novel 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives of the formula (I), ##STR1## wherein X means oxygen or an &gt;NR group, wherein

2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical

The invention relates to, therapeutically active 2-oxo-3,8-diazaspiro[4,5]decane derivatives (I), ##STR1## wherein R means hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two optionally being substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);

2-oxo-3,8-diazaspiro(4,5)decane derivatives, pharmaceutical compositions

The invention relates to novel, therapeutically active 4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives of the compound, ##STR1## wherein X means oxygen or an &gt;NR group, wherein

4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical

The invention relates to novel compounds 1-oxa-2-oxo-8- of the formula (I), ##STR1## wherein X means oxygen or an &gt;NR group, wherein

1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives, pharmaceutical

The invention relates to novel, therapeutically active 4,4-disubstituted piperidine derivatives of the formula (I), ##STR1## wherein R.sup.1 means hydrogen or --CONHR group, wherein

4,4-disubstituted piperidine derivatives, pharmaceutical compositions

The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and stand for hydrogen or halogen or a trihalomethyl, lower alkyl, lower alkoxy, nitro, hydroxyl, aralkyloxy or an 1-(2-propenyl-4-piperazinyl) group;

1,4-Disubstituted piperazines having dopaminergic activity

The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1 and R.sub.2 are the same or different and stand for hydrogen or halogen or a lower alkyl, trihalomethyl or lower alkoxy group. The compounds of the general formula (I) are therapeutically useful for the treatment of diseases arising from a hypofunction of the dopaminergic system.

1,4-disubstituted piperazines, pharmaceutical compositions thereof and

The invention relates to fodder additives comprising a compound inducing the microsomal enzyme system of the liver, preferably a compound of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are identical or different and stand for hydrogen, halogen, trihalomethyl, or alkyl or alkoxy each containing from 1 to 6 carbon atoms;

Fodder additive and a process for the preparation

The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;

Aminoethoxybenzylalcohol derivatives, process for their preparation and

The invention relates to new dialkylaminoalkoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;

Dialkylaminoalkoxybenzylalcohol derivatives, process for their

The invention relates to new aminopropanol derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkoxy having from one to 3 carbon atoms or alkyl having from one to 3 carbon atoms,

1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation

The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,

1,1-diphenylpropanol derivatives, process for their preparation and

The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,

Diethylaminoalkoxybenzhydrol derivatives, process for their preparation

The invention relates to new pyridine derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,

Certain-2-methyl-6-{4-[1-phenyl-1-hydroxypropyl]-phenoxymethyl}pyridines

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

Process for the preparation of 3-trifluoromethyl-and

Growing community of inventors

Budapest, Hungary

Edit Toth