Boehringer Ingelheim International Gmbh

Oblique Therapeutics Ab

Biolipox Ab

Orexo Ab

Galleon Pharmaceuticals, Inc.

Neurad Ltd.

Latvian Institute of Organic Synthesis

Edgars Suna

Benjamin Pelcman

Dirk Stenkamp

Henning Priepke

Roland Pfau

Raimund Kuelzer

Robert Roenn

Dimitrijs Lubriks

Vita Ozola

Henri Doods

Scott L Dax

Juergen Mack

Ivars Kalvins

James Joseph Mencel

William Stafford

Martins Katkevics

Martins Priede

Kristofer Olofsson

Kirill Shubin

Kirsten Arndt

Klaus Klinder

Aigars Jirgensons

Ilona Domracheva

Dace Katkevica

Peteris Trapencieris

Wesley Schaal

Marina Martjuga

Linda Kinena

Gundars Leitis

Iveta Kanepe-Lapsa

Kristaps Jaudzems

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R, R, Rand X have meanings provided in the description, which compounds are useful in the treatment of cancers. 

Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer

Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer

The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.

Breathing control modulating compounds, and methods of making and using same

The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.

Breathing control modulating compounds, and methods of using same

The present invention relates to compounds of general formula I in which A, L, M, Q, Q, Q, R, R, R, R, R, W, X, Y, Z, Z, Zare defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

Compounds

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R, R, R, Rhave meanings given in the description.

Inhibitors of the microsomal prostaglandin E2 synthase-1

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R, R, R, R, R, R, R, Rhave meanings given in the description.

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R, R, R, R, R, R, R, R, R, R, Rhave meanings given in the description.

 There is provided compounds of formula (I), wherein X, Q, T, Y, R, R, R, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

Indoles useful in the treatment of inflammation

There is provided a compound of formula: (I), wherein X, R, R, R, R, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation. 

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Riga, Latvia

Edgars Suna