Warner-Lambert Company

Edgardo Laborde

Mel C Schroeder

Juan C Jaen

Anthony J Thomas

Ruth Bucsh

A compound of the formula ##STR1## wherein * denotes an asymmetric carbon; X is C--H, C--F, C--Cl, C--OCH.sub.3, C--CF.sub.3, or N;

7-substituted quinolones and naphthyridones as antibacterial agents

The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo 2.2.1!heptan-3-one and 1-azabicyclo 2.2.2!heptan-3-one oximes to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.

Preparation of stereochemically pure oximes with muscarinic activity

##STR1## 7-Substituted quinolones and naphthyridones are described as antibacterial agents as well as a process for their manufacture, compositions therefor, wherein the 7-substituent is a pyrrolidine ring substituted at the 3-position by a substituted aromatic hydrocarbon or a heteroaromatic group.

A compound of the formula ##STR1## V, W, Y, and Z are each independently C--H, oxygen, nitrogen, or sulfur; T is C--H or nitrogen;

7-Substituted quinolones and naphthyridones are described as antibacterial agents as well as a process for their manufacture, compositions therefor, wherein the 7-substituent is a pyrrolidine ring substituted at the 3-position by a substituted aromatic hydrocarbon or a heteroaromatic group.

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Canton, MI, United States of America

Edgardo Laborde