Optinetrics, Inc.

Other

Stc.unm

Physical Optics Corporation

Optech Ventures, LLC

Neophotonics Corporation

Intelligent Optical Systems, Inc.

Edgar A Mendoza

Robert A Lieberman

Lothar U Kempen

Steven Roy Julien Brueck

Alexander Neumann

Jeremy Scott Edwards

Yuliya Kuznetsova

C Jeffrey Brinker

Rongchung Tyan

David Mintzer

Thomas C Forrester

Yevgeniy Y Durets

James E Sorenson

Frank W Dabby

Fernando A Sigoli

Anil Menon

Hee Choon Kang

Steven Rj Brueck

Steven RJ Brueck

Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture 'tortuous' nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Innovative nanopore sequencing technology

Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (&#x3e;wavelength), &#x2dc;1-nm aperture 'tortuous' nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Innovative nanopore sequencing technology including a self-assembled porous membrane

The invention discloses multi-channel fiber Bragg grating (FBG) interrogation systems and manufacture thereof. The multi-channel fiber Bragg-grating sensor interrogation unit comprises at least one integrated optic sensor microchip and a signal processing IC-electronics unit in a miniaturized, telecommunications standard, hermetically sealed 2-cm&#xd7;5-cm SFF single fiber package.

Fiber bragg crating sensor interrogation method

A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.

Integrated optic devices and photosensitive sol-gel process for producing integrated optic devices

An integrated bi-directional transceiver device for multiple wavelength optical signals that has a high level of wavelength isolation at the receivers of the device and low cross-talk of light between an external laser transmitter and the receivers. A WDM planar light wave circuit (PLC) assembly combines high spatial light confinement waveguide structures and a variable thickness dielectric wavelength selective filter (WSF) on the surface of the device to reflect a first wavelength signal and to pass a second wavelength signal. Embodiments of the invention include branching waveguide structures and folded path waveguide assemblies with multiple WSF's.

Bi-directional PLC transceiver device

Waveguide structures in which light confinement strength varies along the direction of light propagation are described. The waveguides include a core adapted to propagate light along a path defined by the core and a cladding material that at least partially surrounds the core. The core and the cladding material each have a refractive index profile in the direction of light propagation. One or more of the profiles or lateral core dimensions are varied along the direction of light propagation, thereby causing the degree of light confinement to vary in the direction of light propagation. With such structures it is possible to tailor the velocity of the light propagating through the core and the confinement of the light to the core for any given core cross section. The structures may be used, for example, in mode-matching an input or output of a waveguide and in fabricating compact directional couplers.

Optical waveguide structure

Processes for fabricating integrated optics devices are provided. According to one process, a photosensitive sol-gel glass material including a volatile photosensitizer is prepared. A film of the sol-gel is then produced on a substrate. The film is then imprinted with an image of an optical device by exposing the photosensitive sol-gel film to light energy patterned in the negative or positive image of the desired device, thereby photolyzing photosensitizer within the exposed portion in proportion to the amount of light energy delivered. The image of the written optical device is then fixed in the exposed film, thereby forming a planar device layer having an embedded optical device. The photoinduced refractive index change between the optical device and the surrounding region is preferably greater than or equal to 0.001. A variety of passive and active integrated optic devices may be fabricated using the disclosed processes and are also described.

Integrated optic devices and processes for the fabrication of integrated optic devices

A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, electro-optic, magneto-optic, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.

Thermally-assisted photo-lithographic process using sol-gel derived glass and products made thereby

Thermally-assisted organometallic sol-gel derived glasses have been found to permit fabrication of thin films sufficiently thin for telecom components. Inclusion of a photosensitizer in the film permits light of controlled intensity to modify refractive indices in the film to form useful structures.

Thin film sol-gel derived glass

A method of preparing a multi-layer, crack resistant sol-gel glass derived coating on a substrate by removing the outer periphery of each layer before curing the layer and depositing any succeeding layer.

Crack resistant sol-gel wafer coatings for integrated optics

A partially modified photosensitive monolithic oxide glass apparatus formed through photolithographic imaging. The apparatus may be either a volume apparatus or a layer apparatus. Both types of apparatus may be used to diffuse light in predetermined directions or shapes. The monolithic oxide glass apparatus is capable of withstanding temperatures well beyond glass transition temperatures of plastic light shaping devices and can be formed in convex or concave surfaces through conventionally molding grinding or polishing techniques and can be coated by hot-coating techniques.

Growing community of inventors

Redondo Beach, CA, United States of America

Edgar A Mendoza