Rutgers, The State University of New Jersey

Eddy Arnold

Kalyan Das

Joseph David Bauman

Edmond Joseph LaVoie

Ajit S Parhi

Disha Patel

Hye Yeon Sagong

Suyambu Kesava Vijayan

John E Kerrigan

Cody Kelley

Dishaben V Patel

The invention provides compounds of formula I: and salts and prodrugs thereof wherein R, Xand Xhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones

The invention provides compounds of formula (I) and salts thereof wherein R-Rhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties. 

Therapeutic hydroxyquinolones

The invention provides compounds of formula I: and salts thereof wherein R-Rhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.

Therapeutic catechols

The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties. 

The invention provides inhibitors of influenza endonuclease activity and tools for their discovery.

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New Brunswick, NJ, United States of America

Eddy Arnold