Bayer Aktiengesellschaft

Eckhard Schwenner

Andreas Knorr

Stanislav Kazda

Thomas M Aune

Gaetan Ladouceur

Rainer Gross

Martin Bechem

Matthias Schramm

Hans-Joachim Kabbe

Siegbert Hebisch

Axel Kretschmer

Burkhard Mielke

Udo Stropp

Christoph Schwemler

Johannes-Peter Stasch

Horst Meyer

Jurgen Stoltefuss

Michael Kayser

Wolfgang Springer

Hartmut Stegelmeier

Claudia Hirth

Thorsten Potter

Gunther Kinast

Antonius Lobberding

Winfried Kosch

Antonius L Obberding

Hansjorg Durr

Thorsten P Otter

Hartmut Stagelmeier

The present invention relates to compounds of the general formula (I), ##STR1## in which the radicals have the meaning given in the description, to processes for their preparation and to their use as medicaments.

Nucleic acid-binding oligomers for therapy and diagnosis

The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.

Nucleic acid-binding oligomers possessing C-branching for therapy and

The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.

Nucleic acid-binding oligomers possessing N-branching for therapy and

The anthracene-spiro-pyrrolidines according to the invention are prepared by reacting either anthracene-spiro-furans or unsubstituted anthracene-spiropyrrolidines with appropriately substituted amines or by reacting unsubstituted anthracene derivatives with appropriately substituted methylenepyrrolidines. The substances can be used as active agents in medicaments, in particular for the production of immunomodulating medicaments.

Anthracene-spiro-pyrrolindines

N,N-Disubstitued piperazines are prepared by reacting either the appropriately substituted furans or the N-unsubstituted pyrrolidines with aminoalkylpiperazines. The substances according to the invention can be employed as active agents in medicaments, in particular for the production of immunomodulators.

N,N-disubstituted piperazines

Substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes or N-unsubstituted pyrroloanthracenes with appropriately substituted alkylamines. The compounds can be employed as active ingredients in medicaments, in particular as immunomodulators.

Substituted pyrroloanthracenes and -diones

The piperazine-substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes with piperazinalkylamines or reacting unsubstituted pyrroloanthracenes first with dihalogenoalkyl compounds and then with appropriately substituted piperazines or by reacting furan derivatives first with piperazinalkylamines and then condensing with anthracenes. The new compounds can be employed as active ingredients in medicaments, in particular in immunomodulators.

Piperazine-substituted pyrroloanthracenes

Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,

Amino-esters of dihydropyridines useful for improving circulation in

Hypertension and cardiac insufficiency can be controlled by 4-nitrophenyl-dihydropyridine amides of the formula ##STR1## in which X can be ethylene or the like,

Pharmaceutically active basic nitro-phenyl-dihydropyridine amides

Circulation active dihydropyridine amides of the formula ##STR1## in which R.sup.6 represents a group of the formula --O--(CH.sub.2).sub.n --R.sup.10, --S--(CH.sub.2).sub.n --R.sup.10 --O--SO.sub.2 --(CH.sub.2).sub.n R.sup.10 or --O--CO--(CH.sub.2).sub.n --R.sup.10 in which

Circulation-active basic 4-aryl-DHP amides

Amino-esters of dihydropyridines, and their use as circulatory agents

Novel circulation-active cyclohexenecarboxylates of the formula ##STR1## in which R.sup.1 is an organic radical,

Circulation-active cyclohexenecarboxylates

Circulation active tetrahydropyridines of the formula ##STR1## in which R.sup.1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon atoms and can be interrupted in the chain by an oxygen atom or a sulphur atom and/or can be substituted by halogen, cyano, hydroxyl, acyloxy, nitro or nitrooxy, or by a phenyl, phenoxy, phenylthio or phenylsulphonyl group which is optionally substituted by halogen, cyano, dialkylamino with in each case 1 or 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an .alpha.-, .beta.- or .gamma.-pyridyl group, or by an amino group, this amino group carrying 2 identical or different substituents from the group comprising alkyl with up to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and aralkyl, and these substitutents optionally forming, with the nitrogen atom, a 5- to 7-membered ring which can contain, as a further hetero atom, an oxygen or sulphur atom or an N-phenyl or N-alkyl grouping, this alkyl group containing 1 to 3 carbon atoms,

Circulation-active tetrahydropyridine-3-carbonitrile derivatives

Certain 2h-benzo[a]quinolizin-2-yl-aminoalkyl esters of

Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.

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Wuppertal, Germany

Eckhard Schwenner