Janssen Pharmaceutica Nv

Eckhard Bender

Liliane Amelie Schoofs

Walter Herman Maria Louis Luyten

Mirek Jurzak

Elke J H Clynen

Arjan Buist

Liliane A H Schoofs

Irma Petronella Van Oers

Tom J L Meeusen

Armelle Nathalie Françoise Pindon

Martine Ercken

Geert Luc Baggerman

Walter Herman Luyten

Tom Julia Meeusen

Elke Jenny Clynen

The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.

EPF derived peptides and therapeutic compositions

There is disclosed an isolated or substantially pure form of a nucleic acid molecule encoding a human 5-HTreceptor, which 5-HTreceptor preferably comprises the sequence illustrated in FIG.B. Also provided by the invention are expression vectors incorporating said nucleic acid molecule in addition to transgenic cells, tissues or organisms transfected with the nucleic acid molecule.

Cloning and expression of a novel 5-HT4 receptor

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Beerse, Belgium

Eckhard Bender