Bayer Pharma Aktiengesellschaft

Bayer Intellectual Property Gmbh

Bayer Schering Pharma Ag

Eckhard Bender

Katja Zimmermann

Susanne Röhrig

Christoph Gerdes

Anja Buchmüller

Mark Jean Gnoth

Mario Jeske

Yolanda Cancho Grande

Kersten Matthias Gericke

Dirk Heimbach

Dirk Schneider

Philip Lienau

Ningshu Liu

Stefan Golz

Dmitry Zubov

Ulrich Rester

Mark Meininghaus

Georges Von Degenfeld

Michael Gerisch

Franziska Siegel

Daniel Basting

Dieter Lang

Volkhart Min-Jian Li

William Johnston Scott

Carsten Schmeck

Peter Kolkhof

Knut Eis

Jörg Keldenich

Ludwig Zorn

Kai Thede

Heinrich Meier

Detlev Sülzle

Daniel Meibom

Jens Ackerstaff

Elisabeth Pook

Ingo Flamme

Philipp Buchgraber

Ursula Mönning

Chantal Fürstner

Dagmar Karthaus

Marcus Bauser

Andrea Hägebarth

Simon Holton

Ulf Brüggemeier

Florian Puehler

Anja Richter

József Bálint

Manfred Möwes

Michaela Bairlein

Verena Voehringer

Sarah Wagner

Dimitry Zubov

The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: Lrepresents an optionally substituted methylene or ethylene group; Lrepresents &#x2014;N(H)&#x2014;C(&#x2550;O)&#x2014; or &#x2014;C(&#x2550;O)&#x2014;N(H)&#x2014;; Rrepresents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or &#x2014;N(R7)(Ci-C6-alkyl) group; Rrepresents an optionally substituted 5- or 6-membered heteroaryl group; Rrepresents an optionally substituted phenyl group. 

Compounds

The present invention relates to amido-substituted azole compounds of general formula (I), in which X, X, R, R, R, R, Rand Rare as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients. 

Amido-substituted azole compounds

The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumor disorders.

Substituted piperidines as Par-1 antagonists

The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.

Substituted piperidines

The invention relates to compounds of the formula to processes for the preparation thereof, and to the use thereof for treatment and/or prophylaxis of cardiovascular diseases and tumour diseases.

The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.

Heteroaryl-substituted piperidines

The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors

The invention relates to compounds of the formula (I) to processes for the preparation thereof, and to the use thereof for the treatment of cardiovascular disorders and tumor disorders.

Growing community of inventors

Langenfeld, Germany

Eckhard Bender