Apotex Pharmachem Inc.

Eckardt C G Wolf

Bhaskar Reddy Guntoori

Nageib Mohamed

Gamini Weeratunga

Allan W Rey

Zhi-Xian Wang

Mohammed Abdul Raheem

This invention relates to a process for the preparation of an aminoalkyl phenyl carbamate compound of formula 1, wherein Rand Rindependently are hydrogen or Calkyl; Rand Rare the same or different and each is a lower alkyl; or Rand Rtogether with the nitrogen to which they are attached form a cyclic moiety of a three to eight-member ring, with or without a hetero atom like nitrogen or oxygen; Rand Rindependently are hydrogen, linear, branched or cyclic Calkyl, allyl, propargyl or benzyl; or Rand Rtogether with the nitrogen to which they are attached form a cyclic moiety of three to eight member ring, with or without a hetero atom like nitrogen or oxygen; the carbon center marked with '*' is racemic or enantiomerically enriched (R)- or (S)-configuration; and pharmaceutically acceptable addition salts, and crystalline and amorphous forms thereof comprising the steps of:  

Process for the preparation of phenylcarbamates

The present invention provides a novel and improved process for the preparation of Zonisamide and the intermediates thereof. In one aspect of the present invention, the process provides for: the preparation and isolation of a novel crystalline form of anhydrous 1,2-benzisoxazole-3-methanesulfonic acid of formula 1; the direct chlorination of the acid of formula 1 into its acid chloride of formula 2; and the in situ conversion of the intermediate acid chloride of formula 2 into Zonisamide 

Process for the preparation of zonisamide and the intermediates thereof

A process for the preparation of Balsalazide and its pharmaceutically acceptable salts wherein the reaction comprises:

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Brantford, Canada

Eckardt C G Wolf