The General Hospital Corporation

Cambridge Polymer Group, Inc.

The General Hospital Corporation D/b/a Massachusetts General Hospital

Ebru Oral

Orhun K Muratoglu

Edward T Kopesky

Jeremy V Suhardi

Andrew Freiberg

Harry E Rubash

Henrik Malchau

Ali Eren Atici

Ayse Bakar Atici

Chhavi Gupta

Orthun K Muratoglu

Therapeutic polymeric materials, therapeutic polymeric materials containing medical implants and methods for making the same, and related materials are described. Methods of making medical implants containing additives/antibiotics, therapeutic polymers, and materials used therewith also are described. Methods of spatially controlling additive/antibiotic concentrations, non-homogenous distribution of therapeutic agents in polymeric materials and therapeutic medical implants containing layered constructs of polymeric materials are provided. Therapeutic medical implants containing incorporated therapeutic agents in the polymeric materials, for example, antibiotics into polymeric total joint implants, are useful for delivery of the therapeutic agents into the surrounding mediums.

Methods of making therapeutic polymeric material

This present invention relates to drug eluting polymers, including novel biodegradable drug eluting polymers, which are added to the surface of a medical device to treat device associated complications and to deliver drug locally around the device. Methods of making polymers, for example, drug-eluting polymers, polymer compositions, and materials used therewith also are provided. The drug eluting polymers are obtained from the polymerization of macromonomers made of a connecting moiety, a biodegradable moiety and a cross-linkable moiety that are liquids at a temperature of 10° C. to 40° C.

Drug eluting polymer composed of biodegradable polymers applied to surface of medical device

The inventions provide methods of manufacturing peroxide cross-linked and high temperature melted polymeric material, for example ultra-high molecular weight polyethylene (UHMWPE) containing vitamin E, total joint implants with high wear resistance, high oxidation resistance, and very low concentration of residual by-products, as well as products made thereby.

Di-cumyl peroxide crosslinking of UHMWPE

The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.

Methods of making a layered consolidated UHMWPE for use as a medical implant, and products made by the methods

Methods of making crosslinked polymeric materials and crosslinked interlocked hybrid polymeric materials using photoinitiator, antioxidant, additive, and photoirradiation of polymeric blend and/or interlocked hybrid materials are provided. Methods of spatially controlling macroscopic properties and morphology of polymeric materials, and products made by the methods also are provided.

UV-initiated reactions in polymeric materials

Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.

Peroxide cross-linking and high temperature melting

Methods of making a layered consolidated UHMWPE comprising a pharmaceutical compound

Systems and methods of protecting allograft against radiation damage are disclosed. Systems and methods of incorporating additives such as radioprotectants into allograft tissue are also disclosed. The systems and methods comprise providing an allograft; cleaning the allograft; contacting the allograft with at least one radioprotectant, thereby obtaining a radioprotectant-doped allograft; contacting the radioprotectant-doped allograft with a supercritical fluid, thereby obtaining a radioprotectant doped and homogenized allograft.

Systems and methods of radioprotection of allografts

Methods of making a wear and oxidation resistant medical implant are disclosed.

Antioxidant-stabilized joint implants

The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (&#x3b1;-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (&#x3b1;-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.

Methods for making oxidation-resistant cross-linked polymeric materials

Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.

Spatial control of additives by high temperature

High temperature melting

The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.

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Newton, MA, United States of America

Ebru Oral