Merckle Gmbh

Eberhard P Hofer

Christian Rembe

Erhard Kohn

Peter Gluche

Hartmut Seliger

Raoul Bader

Rudiger Leuner

Hermann Brugger

Stefan Aus Der Wiesche

The invention relates to a device and to a process for the automatic synthesis of macromolecules on a tape-like substrate material ( ). The device has at least one synthesis module ( ) which can be sealed from the outside and comprises reaction chambers ( ) and fluid lines ( ) for filling and emptying the reaction chambers ( ) with and of reaction media, it being possible to introduce the substrate material ( ) into the synthesis module ( ) and bring it into contact with the reaction chambers ( ). Transport means ( ) which are intended to move the substrate material ( ) through a particular distance and can be actuated by a control device are furthermore provided. The invention also relates to the use of such a device for the synthesis of oligonucleotides bound on a functionalized substrate material, in particular the production of oligonucleotide libraries.

Automated macromolecule synthesizing process and device

The invention relates to a microactuator arranged on a thermally insulating layer ( ) and having a resistance layer ( ) made from doped diamond, which is provided with an electrical supply and an electrical leakage ( ).

Microactuator based on diamond

Growing community of inventors

Lonsee, Germany

Eberhard P Hofer