Merz+co. Gmbh & Co.

Stada Arzneimittel Ag

Eberhard Nurnberg

Erhard Seiller

Rolf Dieter Beutler

Thomas Gassenmeier

Gabriele Griessmeyer

Jurgen Ebinger

Harald Perschbacher

Uwe Leonhardt

Bernd Kuhn

Otto P Hornstein

Stefan Ritsert

The invention relates to novel essentially anhydrous oily bath and shower compositions containing a combination of fatty oil and/or fatty or waxy apolar substance, oil-soluble surfactant, and vesicle-forming lipid and, if desired, a cosmetically- or balneologically-active ingredient. When poured into or simply admixed with water, these formulations immediately and automatically, generate dispersed vesicles or liposomes. They exhibit an immediate as well as a prolonged or depot effect, can be used alone or added to or together with existing bath or shower formulations, and are especially suited for use in connection with or as additives to full, partial, or shower baths.

Bath and shower composition having vesicle-forming properties and method

The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release profile and which are characterized by the presence of both a water-soluble and a water-insoluble salt of casein, preferably sodium and calcium caseinate, in the matrix thereof, in broad proportions and in a total amount between 5 and 98% by weight of the composition, and with a process for the production thereof.

Memantine-containing solid pharmaceutical dosage forms having an

The application discloses a process for the manufacture of mechanically-stable, readily-disintegratable tablets made of small preformed, preferably rounded, particles or pellets containing a high percentage of active ingredient in which--prior to compression--the particles are coated with an aqueous or aqueous/organic suspension containing water-soluble polyvinyl alcohol having an ester content of 19.4 to 6.7%, a disintegrant, and finely-divided cellulose, the remainder being excipients such as additional colloids, adjuvants, dyes, and/or flavors and the suspending liquid, and dried, the stable but readily-friable tablet product thus-produced, and a method of delivering an active ingredient by the employment of such a tablet for oral ingestion.

Mechanically-stable, readily-disintegratable tablets made of small

Ambiphilic creams with improved spreading and penetration properties as well as improved tolerance contain a glycerol-monostearate-free water-in-oil emulsifier and glycerol and/or sorbitol. Ambiphilic creams with an isopropyl myristate content have particularly favorable properties.

Ambiphile cream

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Uttenreuth/Weiher, Germany

Eberhard Nurnberg