Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Eberhard Maurer

Rolf Deeg

Urban Schmitt

Sigmar Klose

Wolfgang Rudinger

Bernhard Kopfer

Reiner Babiel

Gunter Pappert

Wolf D Engel

Thomas Geiger

The invention addresses a device for separating magnetic microparticles in a liquid with the aid of a magnetic field. During the separation procedure, the liquid containing the microparticles is located in the tip of the pipette. Moreover, the invention also addresses a method for separating microparticles, and a method for washing microparticles.

Device and method for the separation of magnetic microparticles

For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume. A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.

Process for the determination of an immunologically detectable substance

An analysis element for the determination of an analyte in a liquid sample, especially for medicinal uses. A carrier layer (2) contains, in a reagent domain (4), a reagent applied in a defined pattern by an ink-jet process. The pattern comprises several sets (A, B, C) of compartments (11-20), the compartments (e.g. 11, 13, 15, 17, 19) of the same set (e.g. A) having the same chemical composition, the compartments (11, 13, 15, 17, 19 or 12, 16, 20) of different sets (A or B) containing different reagents and the compartments of different sets being arranged in alteration so that the compartments containing different reagents are close together but nevertheless spatially separated.

Analysis element and process for its manufacture

A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short time whenever a quantity of the liquid is to be ejected. The invention further relates to a device with a disposable jet element which contains prepackaged analytical liquid.

Method for the metered application of a biochemical analytical liquid to

To produce a solid phase coated with an immunologically active substance, a carrier material is absorptively coated with a mixture of an immunologically active substance and a compound which contains at least two functional groups which can be photoactivated and at least one moiety which interacts with the carrier material and the immunologically active substance and it is subsequently irradiated for the cross-linkage.

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Weilheim, Germany

Eberhard Maurer