Bayer Aktiengesellschaft

Bayer Corporation

Lanxess Deutschland Gmbh

Bayar Aktiengesellschaft

Eberhard Kuckert

Herbert Hugl

Wolfgang Podszun

Frank Louwet

Bruno Bomer

Rolf Wehrmann

Horst Berneth

Ludger Heiliger

Florin Seng

Wolfgang Springer

David Zelmanovic

Antonius Lobberding

William Moskalski

Ronny DeClercq

Gunther Beck

Hans J Rosenkranz

Gunter Sackmann

Stephan Michaelis

Hans-Ulrich Siegmund

Wolfgang Ebenbeck

Holger Ohst

Klaus Sommer

Matthias Boll

Jurgen Kocher

Meinhard Rolf

Heinz Kolbl

Dietmar Mobius

Heinrich C Schopper

Gunther Franke

Antonious Lobberding

The present invention relates to a process for preparing high-purity lithium fluoride proceeding from lithium carbonate, and to lithium fluoride having a preferred morphology.

Production of high-purity lithium fluoride

The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution, and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

Monodisperse fluorine-containing synthetic polymer particles having a defined refractive index for use as standards and calibrators in flow cytometry

Synthetic polymer particles for use as standards and calibrators in flow

The invention relates to the preparation, as substituents, of nucleotides possessing a fluorescent coumarin residue, the enzymic incorporation of these nucleotides into nucleic acids and the detection of nucleic acids of defined sequence by hybridization with a complementary, coumarin-labelled nucleic acid.

Sulphocoumarin-containing nucleotides and their use in processes for

The present invention relates to novel, biologically active polymers, methods for their preparation and their use for biochemical identification reactions and/or for further reaction with biologically active molecules such as, for example, proteins or nucleic acids.

Biologically active polymers

Photochemically linkable polymers corresponding to formula (I)

Photochemically linkable polymers

Coumarin deviatives of the formula ##STR1## in which R.sup.1 denotes cyano,

Coumarin derivatives, process for their preparation, their use and

The present invention relates to polymer dyestuffs, i.e. polymer-bound dyestuffs, to a process for their preparation and to their use, for example as markers in analytical procedures. Polymer dyestuffs contain linkable functional groups and are water-soluble under customary conditions of analysis. The polymer portion is usually responsible for this water solubility. The dyestuffs per se are often water-insoluble.

Polymer dyestuffs and preparation and use thereof

The present invention relates to a sensor with a novel construction for a detection method of molecules labelled with fluorescent dye for detecting these dissolved substances or analytes by energy transfer with a simple fluorescence technique and increased sensitivity in the detection as well as versatile use for different tasks and the possibility of reproducible preparation of films bound to solid surfaces.

Optical biosensor and method of use

Polymer-bound dyes, process for their production and use

Growing community of inventors

Leverkusen, Germany

Eberhard Kuckert