Cancer Research Ventures Limited

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Merz+co. Gmbh & Co.

Ruprecht-Karls-universitÄt

Biosphings Ag

Lumavita Ag

Biosphinks Aktiengesellschaft

Deutsches Krebsforschungszentrum - Stiftung Des Öffentlichen Rechts / Universität Heidelberg

Susilo, Rudy, Dr.

Eberhard Amtmann

Rudy Susilo

Gerhard Schilling

Gerhard Sauer

Norbert Frank

Klaus W Hummel

Aubry Miller

Nikolas Gunkel

Michael Morgen

The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.

Compositions comprising a metal source, dithiocarbamate and cyclodextrin

The invention is related to association products of xanthates and cyclodextrins, pharmaceutical formulations made therefrom, and medicaments containing these formulations for treating Alzheimer's, viral, tumor, cardiovascular, and autoimmune diseases such as rheumatism, multiple sclerosis, alopecia areata, lupus erythematosus, stroke, lung edema, or for use as radio-protectors. The association products contain a xanthate of general formula I whereby Rrepresents a possibly substituted aryl or alkyl residue and Rrepresents a metal atom, a possibly substituted alkyl, alkoxy, amino or ammonium group or halogen, and a cyclodextrin, whereby the cyclodextrin can be either a substituted or non-substituted alpha-, beta- or gamma-cyclodextrin. Furthermore, the invention is related to the use of the association products for chemical syntheses.

Associations of xanthogenates and cyclodextrins, and their use

The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.0]-dec-9-yl-xanthogenate, drugs containing exo/exo-tricyclo[5.2.1.0]-dec-9-yl-xanthogenate as active ingredient for the treatment of genital herpes, labial herpes, AIDS, tumors or autoimmune diseases, and methods for the production of pure stereoisomers of tricyclo[5.2.1.0]-decan-9-ol and tricyclo[5.2.1.0]-dec-9-yl-xanthogenate.

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This invention relates to salts of guanidine derivatives of formula R&#x2014;X&#x2014;C(&#x2550;NH)NHZ, wherein X represents a valence bond, &#x2014;CH&#x2014;NH&#x2014;, &#x2014;CH&#x2014;NH&#x2014;NH&#x2014; or &#x2014;CH&#x2550;N&#x2014;NH&#x2014;; R represents a linear or branched C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, adamantyl, norbornyl, tricyclodecyl, benzyl, furyl, pyridyl, anthracyl, naphthyl, phenanthryl, perinaphthyl or quinuclidinyl residue, which can be substituted by one or more hydroxyl groups, C&#x2013;Calkoxy groups, C&#x2013;Calkyl groups and/or one or more halogen atoms or one or more amino groups; Z represents O&#x2014;CO&#x2014;Y, O&#x2014;S(O)&#x2014;Y, or O&#x2014;P(O)(OH)&#x2014;Y; and Y represents a linear or branched C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, benzyl, furyl or pyridyl residue, which can be substituted by one or more hydroxyl groups, carboxylic acid groups, C&#x2013;Calkoxy groups, C&#x2013;Calkyl groups and/or one or more halogen atoms or one or more amino groups. These compounds are useful for treating tumor diseases, autoimmune diseases, cardiovascular diseases, infections, and viral diseases.

Salts of guanidine derivatives and pharmaceutical preparations consisting thereof

The present invention relates to a pharmaceutical preparation containing at least one compound of general formula (I)wherein Rand Rare each independently of each other a straight-chain or branched alkyl residue having 1 to 30 carbon atoms, a straight-chain or branched alkenyl residue having 2 to 30 carbon atoms, a monocyclic or polycyclic alkyl residue having 3 to 30 carbon atoms, a monocyclic or polycyclic alkenyl residue having 4 to 30 carbon atoms, or a monocyclic or polycyclic aromatic residue having 6 to 30 carbon atoms, these residues being optionally substituted by one or several substituents. This invention also relates to the use of the pharmaceutical preparations for the immunosuppressive treatment and for the non-invasive treatment.

Medicament containing platinum complex compounds and the use thereof

The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.

Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions

The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein

Guanidine derivatives, methods of preparing them and their use as drugs

The invention refers to antiviral and antitumor compositions which are useful for the control of viruses and tumors and which, in addition to a known antiviral or antitumor active xanthate, contain an adjuvant which increases its antiviral and antitumor action. The adjuvant is an ionic, preferably an anionic, compound with a lipophilic group and a hydrophilic group, preferably an alkali metal deoxycholate or a compound the lipophilic moiety of which is a straight or branched, saturated or unsaturated, aliphatic group with six to eighteen carbon atoms, and the hydrophilic group of which has one or two carboxyl, sulphate, sulphonate, or phosphate groups, or a pharmaceutically-acceptable salt thereof.

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Heidelberg, Germany

Eberhard Amtmann