Abbott Laboratories Corporation

E.i. Dupont De Nemours and Company

Other

Central Glass Company, Limited

Abbott Laboratories & Central Glass Co Ltd

Earl R Speicher

Rajagopalan Raghavan

Keith R Cromack

David Loffredo

Christopher Bieniarz

Toshikazu Kawai

Steve H Chang

Manami Kobayashi

Shuyen L Huang

Honorate A Stelmach

George M Ramsay

John M Hofstetter

Mary Jane Flament-Garcia

Thomas Barton May

Clayton S Ovenshire

Bernard A Mikrut

Sukumaran K Menon

Kathleen L Olson

Leonard S Rosenberg

James R Waterson

Lawrence John Rhodes

Dietmar M Wagenknecht

Honorats A Stelmach

Dale E Herbranson

Cynthia A Coddington

Mark K Burchett

Cheryl Black

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid

A pharmaceutical product. The pharmaceutical product includes a container constructed from a material containing one or more of polypropylene, polyethylene, and ionomeric resins. The container defines an interior space. A volume of a fluoroether-containing inhalation anesthetic is contained in the interior space defined by the container.

Container for an inhalation anesthetic

The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and ethylene diamine tetra acetic acid; benzethonium chloride; and benzyl alcohol and sodium benzoate.

Propofol composition

The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and sodium ethylene diamine tetraacetate; benzethonium chloride; and benzyl alcohol and sodium benzoate.

Fluoroether compositions and methods for inhibiting their degradation in

The present invention provides novel paclitaxel formulations which may be terminally sterilized and show long term stability in water containing admixtures.

Pharmaceutical compositions containing paclitaxel

Described is a stable pharmaceutical composition of 3-(hydroxymethyl-5,5-diphenylhydantoin disodium phosphate ester, the prodrug of 5,5-diphenylhydantoin (phenytoin) a commonly used drug for the treatment and management of epilepsy and other types of convulsive states. It has been found that degradation of the prodrug to phenytoin can be controlled by controlling the pH of the composition. Controlling the pH to between 8.3 to 9.4 results in the production of diphenylglycinamide as the primary degradant and minimization of degradation to phenytoin. If the pH is maintained at a lower or higher value, then the degradation pattern changes, with earlier than expected product failure.

Stable pharmaceutical composition of

An injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions comprising an effective amount of methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol) for treating such a cardiac condition, said composition comprising about 1 mg to 250 mg of esmolol per milliliter of said injectable pharmaceutical composition; 0.01 to 0.02M buffer; said composition having a pH range of 4.5 to 5.5, the esmolol degrading in aqueous solution to produce 3-[4-(3-propionic acid)phenoxy]-1-isopropylamino-2-propanol hydrochloride, said 3-[4-(3-propionic acid)-phenoxyl]-1-isopropylamino-2-propanol hydrochloride having a pK in the pH range of said composition to thereby act as a secondary buffer to increase the buffer capacity and minimize the change in pH as degradation occurs, whereby the stability of esmolol in an aqueous composition is enhanced.

Stable pharmaceutical composition

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Buffalo Grove, IL, United States of America

Earl R Speicher