Dalhousie University

Treventis Corporation

Earl Martin

Sultan Darvesh

Zdenek Valenta

David Magee

Eric Joy

Ian Macdonald

Ian Pottie

Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimer's Disease and related dementias; especially compounds of Formula (I) wherein Ris selected from the group consisting of hydrogen, cyano, fluoro, iodo, alkyl, and aryl; Ris selected from the group consisting of hydrogen, alkyl, and aryl; X is selected from the group consisting of CH, CHO, oxygen, OCH, CHS, SCH, NH, N-alkyl, and N-aryl; Y is an optional spacer group, absent or selected from the group consisting of oxygen, sulfur, NH, N-alkyl, and N-aryl; and Z is selected from the group consisting of alkyl substituted with cyano, fluoro, or iodo and aryl substituted with cyano, fluoro, or iodo. In a preferred embodiment, Rand Rare hydrogen, X is CHO, Y is absent, and Z is phenyl substituted with fluoro, cyano, or iodo. In some embodiments, Z is more specificallyF-phenyl orI-phenyl orI-phenyl. Other compounds are also provided. 

Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system

Pyridones and their use as modulators of serine hydrolase enzymes

Growing community of inventors

Halifax, Canada

Earl Martin