Eli Lilly and Company

Earl E Ose

Herbert A Kirst

Ronald D Johnson

Stephen H Larsen

Ralph M Kastner

Jan R Turner

Nelson H Ludwig

Methods of controlling Mycoplasma infections which comprise administering to an infected or susceptible warm-blooded animal an effective amount of a new macrocin or lactenocin ester derivative of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; or a pharmaceutically acceptable acid addition salts thereof.

Methods of controlling mycoplasma infections

Antibiotic A53868 factor A, which is N.sup.2 -glycyl-N-(2-methylene-2-phosphonoethyl)leucinamide, and the formula: ##STR1## and the salts thereof, which are useful as antibiotics or as intermediates to antibiotics; methods of preparing A53868 factor A by fermentation of Streptomyces luridus; and the microorganism S. luridus NRRL 15101.

Antibiotic A53868 and process for production thereof

Process for production antibiotic A53868

The antibiotic, avilamycin, is useful in the treatment or prevention of swine dysentery.

Control of swine dysentery

Methods of controlling Pasteurella infections are provided which comprise administering to an infected or susceptible warm-blooded aninal an effective amount of a composition comprising (1) a suitable pharmaceutical vehicle and (2) a compound selected from the group consisting of desmycosin, lactenocin, cirramycin A.sub.1, 23-deoxy-5-0-mycaminosyltylonolide, antibiotic M-4365 G.sub.2, 9-dihydrodesmycosin, 9-dihydrolactenocin, 20-dihydrodesmycosin, 20-dihydrolactenocin, rosaramicin, and the pharmaceutically acceptable acid addition salts of these compounds.

Methods of controlling Pasteurella infections

Method of controlling Pasteurella infections which comprises administering to an infected or susceptible warm-blooded animal an effective amount of 5-O-mycaminosyl tylonolide or a pharmaceutically acceptable acid addition salt thereof.

Method of controlling Pasteurella infections

Method of controlling Ureaplasma infections which comprises administering to an infected or susceptible warm-blooded animal an effective amount of 5-0-mycaminosyl tylonolide or a pharmaceutically acceptable acid addition salt thereof.

Method of controlling ureaplasma infections

Controlled release formulations useful in the prolonged treatment and control of microbial infections in animals are comprised of a microbial agent intimately dispersed throughout a copolymer derived from lactic acid and glycolic acid. A method for providing protection to animals for extended periods of time following a single administration is provided.

Controlled release formulations and method of treatment

Antibiotic compositions comprising tylosin and apramycin are effective in the treatment and control of colibacillosis in weanling pigs, and demonstrate greater effectiveness than apramycin alone or tylosin alone.

Growing community of inventors

Greenfield, IN, United States of America

Earl E Ose