The Broad Institute, Inc.

Harvard College

Washington University

Total Synthesis Ltd.

Eamon Comer

Nobutaka Kato

Benito Munoz

Jeremy Duvall

Jennifer A Beaudoin

Bertrand Braibant

Christina Scherer

Timothy A Lewis

Jun Pu

Matthew Leighty

Marshall Morningstar

Michael Organ

Jessica Bastien

Bruno Melillo

Morgane Sayes

Michelle Palmer

Jose R Perez

Laurence David Sibley

Micah Maetani

Marek Maria Nagiec

Adam Skepner

Sebastian T Le Quement

Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.

Compounds and methods for the treatment of parasitic diseases

Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.

Compounds and methods for the treatment of malaria

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria. 

The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.

Modulators of hepatic lipoprotein metabolism

Compounds for the treatment of malaria

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Cambridge, MA, United States of America

Eamon Comer