Merck + Co., Inc.

E Tracy Jones

Otto D Hensens

Robert A Giacobbe

Isabel Martin

Guy H Harris

Yu L Kong

Gregory L Helms

Deborah L Zink

George M Garrity

Leeyuan Huang

Michael A Goetz

Maria T Diez

Suzanne M Mandala

David L Linemeyer

Francis J Dumont

Claude Dufresne

Mary N Omstead

Wendy S Horn

Walter Rozdilsky

Gino M Salituro

Angeles Cabello

Teresa D Matas

Leslie A Ferrell

Siobhan Stevens-Miles

Leeyan Huang

Isabel M Fernandez

This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

Biologically active compounds isolated from aerobic fermentation of

Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.

Antibiotic agents

Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##

Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists

Two acyclic tricarboxylic acid compounds have been isolated from the fermentation of Sporormiella intermedia. The compounds and their derivatives may be used as antifungal agents, cholesterol lowering agents and as anticancer agents.

Acyclic tricarboxylic acid compounds

Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Process for producing FK-506

This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.

Cholesterol lowering agents

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Solana Beach, CA, United States of America

E Tracy Jones