Temple University

Onconova Therapeutics, Inc.

Other

Icahn School of Medicine at Mount Sinai

Mount Sinai School of Medicine

E Premkumar Reddy

M V Ramana Reddy

Stanley Charles Bell

Stephen Cosenza

Mv Ramana Reddy

M V Reddy

James F Holland

Lawrence Helson

Lewis R Silverman

Natarajan Dhanasekaran

Stephen C Cosenza

Kimi Hatton

Svetlana Zinzar

Antonio Toscani

Moole V Reddy

Scott K Shore

Lance H Leopold

Stacey J Baker

Compounds according to Formula I are provided: and salts thereof, wherein R, R, R, R, R, R, R, A, X and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula I.

2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Compounds according to Formula I are provided: and salts thereof, wherein Q, Q, R, R, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).Q-X&#x2014;Y&#x2014;CHR&#x2014;CHR-Q&#x2003;&#x2003;(I)

Substituted alkyl diaryl derivatives, methods of preparation and uses

This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer.

Pyrimidine compounds as kinase inhibitors

The present invention relates to compounds according to Formula I: and salts thereof, wherein R, R, R, R, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof

Compounds according to Formula (I), as well salts thereof: wherein Rand Rare as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided. 

[object Object]

Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R, R, and Arare as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided. 

Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof

Compounds useful as antiproliferative agents according to formula (I): wherein Ar, Ar, Ar, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided. 

Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof

Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein Ris selected from the group consisting of &#x2014;NH, &#x2014;NH&#x2014;CH&#x2014;COH, &#x2014;NH&#x2014;CH(CH)&#x2014;COH, and &#x2014;NH&#x2014;C(CH)&#x2014;COH, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.

Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia

Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X, X, R, R, R, R, R, R, R, R, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones

Compounds of Formula I: wherein R, R, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.

Heteroaryl sulfones and sulfonamides and therapeutic uses thereof

&#x3b1;,&#x3b2;-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar, Ar, X, n, * and R are as defined herein, are prepared by dehydration of &#x3b2;-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.

Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis

Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein Ris selected from the group consisting of &#x2014;OH, &#x2014;NH, &#x2014;NH&#x2014;CH&#x2014;COH, &#x2014;NH&#x2014;CH(CH)&#x2014;COH, and &#x2014;NH&#x2014;C(CH)&#x2014;COH, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.

Composition and methods for the treatment of proliferative diseases

3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof

&#x3b1;,&#x3b2;-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: 

Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof

Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

Growing community of inventors

Villanova, PA, United States of America

E Premkumar Reddy