University of Arkansas

E Kim Fifer

Cesar M Compadre

Philip J Breen

Hamid Salari

Danny L Lattin

Yanbin Li

Michael F Slavik

Timothy J O'Brien

Amy L Waldroup

Kathleen Gilbert

Thomas F Berg

Phillip V Engler

Mike Slavik

A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

Concentrated, non-foaming solution of quaternary ammonium compounds and methods of use

A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

The present invention provides a series of compounds having structural formulaswherein nis 1 to 5, nis 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R' is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, nis not 1; and wherein X and R&#x2032; are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in a n individual.

Derivatives of butyric acid and uses thereof

Concentrated, non-foaming solution of quarternary ammonium compounds and methods of use

Derivatives of butyric acid

A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin-producing Escherichia, and pathogenic toxin-producing Escherichia, such as 0157:H7; fungi, such as Aspergillus flavus and Penicillium chrysogenum; and parasites, such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit. One of the treatment methods is spraying quaternary ammonium compounds on the food products to prevent broad spectrum foodborne microbial contamination. New formulations of quaternary ammonium compounds combined with glycerin and/or ethyl alcohol provides a concentrated formulation for industrial use and a diluted formulation for use in spraying methods.

Method for the broad spectrum prevention and removal of microbial

A composition and a method of using the composition for removal and prevention of broad spectrum foodborne microbial contamination in meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from poultry and meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing Escherichia coli O157:H7 contamination from meat and poultry products. One of the treatment methods is spraying quaternary ammonium compounds on the poultry and meat products to prevent broad spectrum foodborne microbial contamination. The treatment methods can contact the meat products with the quaternary ammonium compounds for less than 10 minutes and still obtain significant reduction of viable foodborne microorganisms. New formulations of quaternary ammonium compounds combined with glycerin and/or ethyl alcohol provides a concentrated formulation for industrial use and a more viscous formulation for use in spraying methods.

A composition and method for removing and preventing Salmonella contamination of meat products, in particular poultry. The composition comprises an effective amount of a quaternary ammonium compound in an aqueous solution. The quaternary ammonium compound are selected from the group consisting of alkylpyridinium, tetra-alkylammonium, and alkylalicyclic ammonium salts. Preferably, the quaternary ammonium compounds are cetylpyridinium chloride (CPC) and cetylpyridinium bromide (CPB). The method comprises treating meat and poultry products with an effective amount of the quaternary ammonium compound in an aqueous solution. Mutagenicity studies are also disclosed.

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North Little Rock, AR, United States of America

E Kim Fifer