University of Pennsylvania

Harvard College

E James Petersson

Alan Saghatelian

The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.

Thioamide-modified peptides and uses thereof

Method of stabilizing a bioactive peptide against protease hydrolysis

The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is derivatized with the molecule.

Growing community of inventors

Wynnewood, PA, United States of America

E James Petersson