International Business Machines Corporation

Globalfoundries Inc.

Institute of Bioengineering and Nanotechnology, Biomedical Sciences Institute

Agency for Science, Technology and Research

Energy Materials Corporation

Agency for Science, Technology

Dylan J Boday

Rudy J Wojtecki

Jeannette M Garcia

James L Hedrick

Joseph Paul Kuczynski

Jason T Wertz

Robert E Meyer, Iii

Timothy Christopher Mauldin

Jing Zhang

Mareva B Fevre

Daniel James Winarski

Anna Wanda Topol

Stephen Leonard Schwartz

Icko E T Iben

Yi Yan Yang

Nathaniel H Park

Timothy Jerome Tofil

Shawn Michael Nave

Wayne Isami Imaino

David Berman

Gavin O Jones

Andrew Stuart Green

Willy Chin

Brandon M Kobilka

Prabjit Singh

Alshakim Nelson

Samuel R Connor

Chuan Yang

Wayne Alan McKinley

Mu San Zhang

Robert J Ono

James Lupton Hedrick

Sandra Lynn Waters

Michael J Ellsworth, Jr

Robert E Simons

Levi A Campbell

Roger R Schmidt

Mark Alfred Lantz

Milnes P David

Thomas Guthrie Zimmerman

Lee Curtis Randall

Dustin W Demetriou

Srinivas Babu Tummalapenta

Diana Joyce Hellman

Wei Cheng

Hamza Yaswi

Zhen Chang Liang

Ashlynn Lingzhi Lee

Myron H Gentrup

Bradford O Brooks

William Thomas Bandy, Iv

Xiyu Ke

Shaoqiong Liu

Joseph Kuczynski, Jr

Eunice Leong

Yang Chuan

YiYan Yang

Louie Arthur Dickens

Douglas A Loy

Steven Mark Groff

Sassan K Shahidi

Zhi Xiang Voo

Richard Alex West

Shrinivas Venkataraman

Icko Eric Timothy Iben

Mark Anthony Marnell

Peter John Golcher

Icko Et Iben

Jeanette M Garcia

Eunice Leong Jiayu

Jason Wertz

Tara L Awezec

Joyce L S Tang

A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.

Stimulus-responsive micellar carrier

In an embodiment is provided a polymer that includes a plurality of N-J-N or N&#x2014;C&#x2014;S repeating units, wherein each J is independently a carbon atom, an alkyl group, or an aryl group; a plurality of hydrophilic groups bonded with the repeating units; and a plurality of hydrophobic groups bonded with the hydrophilic groups and the repeating units. In another embodiment is provided hydrogels of such polymers. The hydrogels may be used as delivery vehicles for various payloads. In another embodiment is provided methods of forming such polymers.

Hydrogels from dynamic covalent networks

A thermal interface material (TIM) includes a modified release layer having an organosilane-coated surface covalently bound to a TIM formulation layer. The modified release layer may be formed by applying an organosilane (e.g., vinyltriethoxysilane) to the surface of a thermally conductive release layer (e.g., aluminum foil). The organosilane reacts with hydroxyl groups on the surface of the thermally conductive release layer. The TIM formulation layer may be formed by applying a TIM formulation (e.g., a graphite TIM formulation) containing an unsaturated monomer (e.g., methyl acrylate) to the organosilane-coated surface of the modified release layer, and then curing the TIM formulation so that the unsaturated monomer of the TIM formulation reacts with the organosilane-coated surface of the modified release layer.

Thermal interface material (TIM) with thermally conductive integrated release layer

Materials which react with ('scavenge') sulfur compounds, such as hydrogen sulfide and mercaptans, are useful for limiting sulfur-induced corrosion. Surface-modified particles incorporating a hexahydrotriazine moiety are disclosed and used as sulfur scavengers. These surface-modified particles are used a filter media in fixed filter systems and as additives to fluids including sulfur compounds. The hexahydrotriazine moiety can react with sulfur compounds in such a manner as to bind sulfur atoms to the surface-modified particles, thus allowing removal of the sulfur atoms from fluids such as crude oil, natural gas, hydrocarbon combustion exhaust gases, sulfur polluted air and water. The surface-modified particles may, in general, be sized to allow separation of the particles from the process fluid by sedimentation, size-exclusion filtration or the like.

Sulfur scavenging materials

Materials and methods for preparing a payload-containing microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures are disclosed. To an HT small molecule or a HA small molecule, or a combination thereof, in a solvent is added a cross-linking agent, NHCl, and a copolymer. The solution is acidified, and a payload agent is added. The HT small molecule and HA small molecule may have orthogonal functionality.

Method to generate microcapsules with hexahydrotriazine (HT)-containing shells

In an embodiment, an article of manufacture includes a first component, a second component, and a thermal interface material. The thermal interface material is disposed between the first component and the second component and includes a polymeric phase-change material. In another embodiment, an article of manufacture includes a first component, a second component, and a thermal interface material disposed between the first component and the second component, the thermal interface material including a polymeric phase-change material, the polymeric phase-change material including a block copolymer formed from a diene, the diene formed from a vinyl-terminated fatty acid monomer having a chemical formula CH&#x2014;R&#x2014;C(O)OH and an ethylene glycol monomer having a chemical formula CHO.

Thermal interface materials including polymeric phase-change materials

According to one embodiment, a magnetic recording medium includes: a substrate; an underlayer positioned above the substrate; a magnetic recording layer positioned above the underlayer; and a plurality of conductive polymers dispersed within the substrate, the underlayer, the magnetic recording layer, the substrate and the underlayer, the substrate and the magnetic recording layer, the underlayer and the magnetic recording layer, or the underlayer, the magnetic recording layer, and the substrate. In addition, the conductive polymers are dispersed such that a concentration of the conductive polymers has a gradient in a single one of the layers in a thickness direction.

Conductive polymers for use in magnetic media

Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.

Macromolecular chemotherapeutics

A carbene-coated metal foil is produced by applying an N-heterocyclic carbene (NHC) compound to one or more surfaces of a metal foil (e.g., an electrodeposited copper foil having a surface that is smooth and non-oxidized). The NHC compound contains a matrix-reactive pendant group that includes at least one of a vinyl-, allyl-, acrylic-, methacrylic-, styrenic-, amine-, amide- and epoxy-containing moiety capable of reacting with a base polymer (e.g., a vinyl-containing resin such as a polyphenylene oxide/triallyl-isocyanurate (PPO/TAIC) composition). The NHC compound may be synthesized by, for example, reacting a halogenated imidazolium salt (e.g., 1,3-bis(4-bromo-2,6-dimethylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride) and an organostannane having a vinyl-containing moiety (e.g., tributyl(vinyl)stannane) in the presence of a palladium catalyst. In some embodiments, an enhanced substrate for a printed circuit board (PCB) is produced by laminating the carbene-coated metal foil to a substrate that includes glass fiber impregnated with the base polymer.

Coating metal foil with N-heterocyclic carbene compounds containing organic functionalities for improving metal-to-resin adhesion

In an embodiment, a polymeric material includes a plurality of hemiaminal units bonded together by a first linkage and a second linkage, wherein the first linkage is thermally stable and resistant to bases and the second linkage is thermally degradable and degradable by a base. In another embodiment, a method of forming nanoporous materials includes forming a polymer network with a chemically removable portion. The chemically removable portion may be polycarbonate polymer that is removable on application of heat or exposure to a base, or a polyhexahydrotriazine (PHT) or polyhemiaminal (PHA) polymer that is removable on exposure to an acid. Removing any portion of the polymer results in formation of nanoscopic pores as polymer chains are decomposed, leaving pores in the polymer matrix.

Porous/nanoporous PHT

This disclosure describes new compositions and methods related to photoresponsive poly(hexahydrotriazines) and related polymers. In an embodiment, a method of patterning a substrate includes forming a liquid poly(hemiaminal) material by a process that includes forming a reaction mixture comprising a polar solvent, paraformaldehyde, and an aminobenzene compound having photoreactive groups, and heating the reaction mixture at a temperature up to 50&#xb0; C. The method further includes applying the liquid poly(hemiaminal) material to a substrate; patterning the liquid poly(hemiaminal) material with UV light; and curing the liquid poly(hemiaminal) material to form a cured poly(hexahydrotriazine) polymer.

Photoresponsive hexahydrotriazine polymers

Described are embodiments of an invention for detecting target antigens in a biological sample using a sample assembly. Detection may be accomplished by performing a method comprising: sweeping a head module over the sample assembly, wherein said head module includes at least one magneto-resistive read sensor configured to detect target antigens via nanoparticles within the sample assembly; and detecting at least one particular antigen among the target antigens. Preferably, detecting the target antigens via the nanoparticles is based at least in part on detecting unique magnetic properties of particular nanoparticles specifically associated with different types of the target antigens. Detection using a magnetic read/write head in the sample assembly facilitates automation of sample detection with high speed and fidelity. Corresponding systems are also disclosed.

Trenched sample assembly for detection of analytes with electromagnetic read-write heads

Polyhemiaminal (PHA) and polyhexahydrotriazine (PHT) materials are modified by 1,4 conjugate addition chemical reactions to produce a variety of molecular architectures comprising pendant groups and bridging segments. The materials are formed by a method that includes heating a mixture comprising solvent(s), paraformaldehyde, aromatic amine groups, aliphatic amine Michael donors, and Michael acceptors, such as acrylates. The reaction mixtures may be used to prepare polymer pre-impregnated materials and composites containing PHT matrix resin.

Polyhemiaminal and polyhexahydrotriazine materials from 1,4 conjugate addition reactions

Silica-based organogels, including aerogels, incorporating hexahydrotriazine and/or hemiaminal species are described. These organo-silica gel materials can have applications as insulating materials. In a particular example, an aerogel includes silica groups and a hexahydrotriazine moiety with at least one nitrogen atom that is covalently linked to a silica group. Methods of making such silica-based organogels are also described.

Silica-based organogels via hexahydrotriazine-based reactions

Growing community of inventors

Tucson, AZ, United States of America

Dylan J Boday