Harvard College

Massachusetts Institute of Technology

Genzyme Corporation

The General Hospital Corporation

Dyann F Wirth

George M Whitesides

Charles R Mace

Ashok A Kumar

Ralph Mazitschek

Cassandra Celatka

Jon Clardy

Renato Tony Skerlj

Roger Wiegand

Cecilia M Bastos

Yibin Xiang

Jon C Clardy

Joseph Cortese

N Connor Payne

Mary Lynn Baniecki

Mark A Tye

Sofia A Santos

Sameer Urgaonkar

Elyse M J Bourque

Michael L Booker

Vishal P Patel

Elyse MJ Bourque

The present application provides compounds, such as compounds of Formula Ia, which are inhibitors of aminoacyl tRNA-synthetase (e.g., prolyl-tRNA-synthetase), and which are useful for treating disorders associated with aminoacyl tRNA-synthetase activity and/or expression. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also provided.

Inhibitors of prolyl-tRNA-synthetase

The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.

Density-based separation of biological analytes using mutliphase systems

A kit for separating a sample comprising one or more biological analytes of interest using a multi-phase system comprising: a) two or more phase components selected from the group consisting of a polymer, a surfactant, and combinations thereof; b) optionally a tag molecule capable of binding the one or more biological analytes of interest; and c) instructions for: (i) combining the two or more phase-separated solutions with a common solvent to create a multi-phase system; (ii) optionally, combining the biological analyte of interest and tag molecule, and (iii) separating the biological analyte of interest from the sample.

Kit for density-based separation of biological analytes using multiphase systems

Density-based separation of biological analytes using multiphase systems

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)&#x2014;The values and preferred values of the variables in Structural Formula I are defined herein. 

2-aminoindole compounds and methods for the treatment of malaria

Inhibitors of dihydroorotate dehydrogenase (DHODH) for theenzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.

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Dyann F Wirth