Targacept, Inc.

R.j. Reynolds Tobacco Company

Dwo Lynm

Gary Maurice Dull

Craig Harrison Miller

Jeffrey Daniel Schmitt

Lan Miao

Thomas Jeffrey Clark

William Scott Caldwell

Balwinder Singh Bhatti

Brian M Lawrence

Chi-Kuen Shu

Carl C Morrison

Gary Dwight Byrd

Joyce R Durham

Ronald W Hutcherson, Sr

Thomas Jeff Clark

The present invention relates to diazabicyclic compounds, preferably to N-aryl diazabicyclic compounds. Of particular interest are 2-pyridinyl diazabicyclic compounds, such as (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. Other exemplary compounds of the present invention include (1S,4S)-2-(5-(4-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(3-thienyl)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(4-fluorophenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, and (1S,4S)-2-(5-benzoyl-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. The present invention also relates to prodrug derivatives of the compounds of the present invention.

Pharmaceutical compositions and methods for use

Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (2S)-(4E)-N-methyl-5-&lsqb;3-(5-isopropoxy-1-oxopyridin)yl)&rsqb;-4-penten-2-amine, (4E)-N-methyl-5-(3-(1-oxopyridin)yl)-4-penten-2-amine, (4E)-N-methyl-5-(3-(5-((carboxymethyl)oxy)pyridin)yl)-4-penten-2-amine and (4E)-N-methyl-5-(3-(1-oxopyridin)yl)-4-penten-2-amine.

Oxopyridinyl pharmaceutical compositions and methods for use

The present invention relates to diazabicyclic compounds, and preferably N-aryl diazabicyclic compounds. Of particular interest are 2-pyridyl diazabicyclic compounds, such as (1S,4S)-2-(3-pyridyl)-2,5-diazabicyclo&lsqb;2.2.1&rsqb;heptane. Other exemplary compounds of the present invention include: (1S,4S)-2-(5-(4-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo&lsqb;2.2.1&rsqb;heptane, (1S,4S)-2-(5-pyrimidinyl)-2,5-diazabicyclo&lsqb;2.2.1&rsqb;heptane and (1S,4S)-2-(6-chloro-3-pyridazinyl)-2,5-diazabicyclo&lsqb;2.2.1&rsqb;heptane. The present invention also relates to prodrug derivatives of the compounds of the present invention.

A process is provided for treating tobacco material for use in a smoking article comprising the step of applying a flavorful and aromatic casing and top dressing composition comprising a weak ammonium salt and a sugar or sugar derivative to a tobacco material. The present also provides a smoking article including tobacco material wherein the tobacco material is in intimate contact with a casing and top casing composition comprising a weak ammonium salt and a sugar or sugar derivative.

Tobacco treatment process

A cigarette having internal heat sinks of aluminum mesh and a section of carbonized flue-cured tobacco stem material containing adsorbed nicotine produces smoke having lower TPM and higher nicotine than smoke from conventional cigarettes.

Cigarette

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Winston-Salem, NC, United States of America

Dwo Lynm