Agilent Technologies, Inc.

United Science, LLC

Dwight Stoll

Konstantin Shoykhet

Klaus E Witt

Stephan Buckenmaier

Thomas Ortmann

Sascha Lege

Jonathan Mark Thompson

Konstantin Shoyket

Stephan Buckenmeier

A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase. At least one of the mobile phase portions is arranged directly next to the fluidic sample and has a higher solvent strength compared to a solvent of the fluidic sample.

Bracketing fluidic sample using strong solvent

A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.

Fluid processing with withdraw-transfer modulation

A sample separation apparatus includes a first-dimension separation unit for separating the fluidic sample, having a first-dimension outlet for outputting the fluidic sample or fractions thereof, and a second-dimension separation unit for further separating the fluidic sample or fractions thereof. The second-dimension separation unit has a second-dimension inlet fluidically coupled to the first-dimension outlet. A modulation unit, coupled between the first-dimension outlet and the second-dimension inlet at a first coupling point, is configured for withdrawing fluid from the first coupling point and for ejecting fluid into the first coupling point. A second-dimension fluid drive is coupled to a second coupling point located between the first-dimension outlet and the second-dimension inlet and downstream from the first coupling point. The second-dimension fluid drive is configured for generating a fluid flow for driving at least part of the fluidic sample after treatment by the first-dimension separation unit through the second-dimension separation unit.

Two-dimensional fluid separation with push-pull modulation

A multidimensional sample separation apparatus includes a first separation dimension for separating a fluidic sample, a second separation dimension for further separating the fluidic sample, a switching mechanism, and a control unit. The first separation dimension includes a first fluid drive unit and a first sample separation unit. The second separation dimension includes a second fluid drive unit for driving the separated fluidic sample, and second and third sample separation units each configured for further separating the separated fluidic sample. The switching mechanism is configured for selectively switching an outlet of the first separation dimension in fluid communication with a selected one of the second sample separation unit and/or the third sample separation unit. The control unit is configured for controlling a pressure at inlets of the second sample separation unit and the third sample separation unit to be substantially the same at least at the time of the switching.

Multidimensional sample separation with pressure adjustment

A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.

HPLC sample introduction with bypass channel

A fluid processing device () for processing fluid, wherein the fluid processing device () comprises a first fluid drive unit () configured for driving a first fluid along a first flow path (), a second fluid drive unit (') configured for driving a second fluid along a second flow path (), and a fluidic switch () fluidically coupled to the first flow path () and to the second flow path () and configured for being switchable for transferring first fluid from the first flow path () into the second flow path () without interruption of fluid flow along at least one of the first flow path () and the second flow path ().

Uninterrupted fluid flow while modulating fluid

A composite particulate material useful in analytical separations processes includes a carbon coating deposited through chemical vapor deposition on a substantially metal-free inorganic oxide particle. The resultant laminate material may be tuned for desired sorption rates and selectivities with respect to analytes of interest.

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St. Peter, MN, United States of America

Dwight Stoll